Abstract:
:The purpose of the study is to understand the effect of altitude on the performance of selected pressurized metered dose inhalers (pMDIs) and dry powder inhalers (DPIs). A testing apparatus that created consistent breath profiles through the Alberta Idealized Throat was designed to test five pMDIs and two DPIs at altitudes of 670, 2450, 3260, and 4300 m. Both gravimetric and chemical assays were conducted to determine the in vitro lung dose. Additionally, spray duration and shot weight for pMDIs and device resistance for DPI were measured. There was no significant change in in vitro lung dose for any of the pMDIs tested. Shot weight and spray duration were unaffected. The device resistance of the DPIs decreased with increasing altitude and was successfully modeled as a function of ambient pressure. The in vitro lung dose of both DPIs showed no significant change when operated with an inhaler pressure drop of 4 kPa, but for the Bricanyl(®) Turbuhaler(®), a significant decrease occurred when matching the volumetric inspiratory flow rate to that of the baseline altitude.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Titosky JTF,Morin CMD,Suderman JD,Olfert JS,Finlay WH,Vehring Rdoi
10.1002/jps.24032subject
Has Abstractpub_date
2014-07-01 00:00:00pages
2116-2124issue
7eissn
0022-3549issn
1520-6017pii
S0022-3549(15)30530-Xjournal_volume
103pub_type
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