Modified cellulose II powder: preparation, characterization, and tableting properties.


:The reaction of UICEL-A/102, a cellulose II powder recently prepared from Avicel(R) PH-102 by treatment with an aqueous sodium hydroxide solution, with glutaraldehyde in 0.01 N HCl has been investigated to improve its binder properties, without adversely affecting the rapid disintegration characteristic. The results showed that UICEL-A/102 and glutaraldehyde when reacted in a 1:0.6 weight ratio at 100 degrees C for 8.5 h produces a product, (hereinafter referred to as UICEL-XL), that, compared to UICEL-A/102, had a lower degree of polymerization, higher crystallinity, lower bulk density, lower tapped density, and higher porosity. Further, it showed lower yield pressure and higher crushing strength, and tensile strength values, indicating that UICEL-XL is more compressible and compactable than the starting material, UICEL-A/102. A comparison of "in-die" and "out-of-die" Heckel data indicated UICEL-XL to be less elastic than UICEL-A/102. Both UICEL-XL and UICEL-A/102 showed similar moisture sorption isotherms, and their compacts disintegrated rapidly in water. In conclusion, the glutaraldehyde-treated cellulose II powder not only serves as good a disintegrant as the untreated cellulose powder but also possesses superior binder properties.


J Pharm Sci


de la Luz Reus Medina M,Kumar V




Has Abstract


2007-02-01 00:00:00














  • Colorimetric acetaminophen determination in pharmaceutical formulations.

    abstract::Different approaches for the colorimetric determination of acetaminophen, based on its coupling with diazotized o-nitroaniline, are described. Copper(II) chelation with the coupled compound makes the method highly selective. Sensitivity is increased when the acetaminophen assay is carried out indirectly through the de...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Belal S,Elsayed MA,El-Waliely A,Abdine H

    更新日期:1979-06-01 00:00:00

  • Synthesis, physicochemical properties, and antitumor activities of analogs of 1-phenyl-3-benzyl-3-methyltriazenes.

    abstract::To study the effect of substituents on the antitumor activities of analogs of 1-phenyl-3-benzyl-3-methyltriazenes, a series of compounds was designed and synthesized in which the substituent on the 1-phenyl was an electron-withdrawing group and the substituent on the 3-benzyl had a broad range of physicochemical prope...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Dunn WJ 3rd,Greenberg MJ

    更新日期:1977-10-01 00:00:00

  • Identification of degradation products in a phenylbutazone tablet formulation.

    abstract::Two previously reported but unidentified phenylburazone degradation products were isolated from a tablet that was stored at 60 degrees for 203 days. The compounds, alpha-(N-phenylcarbamoyl)-N-caproylhydrazobenzene and alpha-hydroxy-alpha-(N-phenylcarbamoyl)-N-caproylhydrazobenzene, were isolated by chromatography, ide...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Matsui F,Robertson DL,Poirier MA,Lovering EG

    更新日期:1980-04-01 00:00:00

  • A lamellar liquid crystal with fosinopril sodium.

    abstract::The location and conformation of fosinopril sodium (FS) in a lamellar liquid crystal of water, sodium dodecyl sulfate, and decanol was studied by low-angle X-ray diffraction. The result showed the FS molecule to be located within the amphiphilic part of the liquid crystalline structure with the polar parts anchored at...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Friberg SE,Moaddel T,Morris KR,Abramowitz R,Amsberry KL

    更新日期:1994-05-01 00:00:00

  • Pharmacokinetics and disposition of a localized lymphatic polymeric hyaluronan conjugate of cisplatin in rodents.

    abstract::Cisplatin (CDDP) is an effective anticancer agent for many solid tumors but has significant systemic toxicity limiting its use in many patients. We have designed a loco-regional delivery system to increase platinum levels in the lymphatics, where early metastasis is most likely to occur, while reducing systemic toxici...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Cai S,Xie Y,Davies NM,Cohen MS,Forrest ML

    更新日期:2010-06-01 00:00:00

  • Stability-indicating assay for phenylbutazone: high-performance liquid chromatographic determination of hydrazobenzene and azobenzene in degraded aqueous phenylbutazone solutions.

    abstract::A high-performance liquid chromatographic method was developed for the simultaneous determination of azobenzene, hydrazobenzene, and four other decomposition products in phenylbutazone injectable formulations. Separation was achieved on a C18 column, with 0.1 M Tris-citrate buffer (pH 5.25) and acetonitrile (52:48), a...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Fabre H,Hussam-Eddine N,Mandrou B

    更新日期:1984-12-01 00:00:00

  • Synthesis of 4-substituted aminoquinoline-3-carboxylates as potential antimicrobial agents.

    abstract::A series of 4-substituted aminoquinoline-3-carboxylates was prepared and evaluated for antimicrobial activity. Four of the compounds (VIII, XIII, XV, and XXIII) exhibited low activity against Staphylococcus aureus. ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Marecki PE,Bambury RE

    更新日期:1984-08-01 00:00:00

  • Preparation and evaluation of Eudragit gels. III: Rectal gel preparations for sustained release of pentoxifylline.

    abstract::A novel method was established for the preparation of Eudragit S, Eudragit L, and Eudispert high-viscosity (hv) hydrogel and xerogel preparations containing a medicinal component such as pentoxifylline (an agent that improves cerebral microcirculation). A significant correlation was found between the in vitro mean dis...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Kim NS,Kawata M,Uchida T,Goto S

    更新日期:1992-06-01 00:00:00

  • Synthesis of d-pilocarpine-N-14CH3.

    abstract::The total synthesis of d-pilocarpine specifically labeled as N-14CH3 is reported. dl-Homopilopic acid was prepared as a key intermediate and resolved into the d-enantiomer via the alpha-methylbenzylamine salt. The penultimate intermediate, 2-mercaptopilocarpine, was desulfurized by oxidation with dilute hydrogen perox...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: DeGraw JI,Engstrom JS,Willis E

    更新日期:1975-10-01 00:00:00

  • Paper chromatographic determination of chlortetracycline.

    abstract::Chlortetracycline was successfully separated from its degradation products and from other tetracyclines on a paper chromatogram previously impregnated with a mixture of edetate disodium and urea solution in pH 5.0 McIlvaine buffer. Chlortetracycline separation from its degradation products and from both tetracycline a...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Youssef MK,Attia IA,Safwat S

    更新日期:1978-04-01 00:00:00

  • Fusion of disubstituted benzenes.

    abstract::The entropy of fusion of 84 disubstituted benzenes was essentially constant and independent of the participation of the compounds in intramolecular or intermolecular hydrogen bonding. It was also independent of the shapes, sizes, and dipole moments of the rigid molecules studied. While the entropy of fusion was indepe...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Martin E,Yalkowsky SH,Wells JE

    更新日期:1979-05-01 00:00:00

  • Effect of dipolar aprotic permeability enhancers on the basal stratum corneum.

    abstract::The effect of dimethyl sulfoxide, dimethyl formamide, and dimethyl acetamide on the basal stratum corneum of excised nude mouse skin was investigated. All of these dipolar aprotic solvents caused a swelling of the basal stratum corneum cells and a disruption of the normal keratin pattern. This behavior suggests that d...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Sharata HH,Burnette RR

    更新日期:1988-01-01 00:00:00

  • Regulation of Tight-Junction Integrity by Insulin in an In Vitro Model of Human Blood-Brain Barrier.

    abstract::Although insulin receptor is expressed at the human blood-brain barrier (BBB), the physiological and pathologic roles of insulin signaling in biologic responses at the BBB remain unclear. Here, we investigate insulin signaling at the human BBB using human cerebral microvascular endothelial cell line (hCMEC/D3) as a we...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Ito S,Yanai M,Yamaguchi S,Couraud PO,Ohtsuki S

    更新日期:2017-09-01 00:00:00

  • Quantitative expression of human drug transporter proteins in lung tissues: analysis of regional, gender, and interindividual differences by liquid chromatography-tandem mass spectrometry.

    abstract::The purpose of the present study was to clarify the expression levels of transporter proteins in human lung tissue and to analyze regional and interindividual differences in primary cultured epithelial cells. Organic cation/carnitine tranporter 1 (OCTN1) protein expression was highest (2.08 ± 1.19 fmol/μg protein) in ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Sakamoto A,Matsumaru T,Yamamura N,Uchida Y,Tachikawa M,Ohtsuki S,Terasaki T

    更新日期:2013-09-01 00:00:00

  • Head to head comparison of the formulation and stability of concentrated solutions of HESylated versus PEGylated anakinra.

    abstract::Although PEGylation of biologics is currently the gold standard for half-life extension, the technology has a number of limitations, most importantly the non-biodegradability of PEG and the extremely high viscosity at high concentrations. HESylation is a promising alternative based on coupling to the biodegradable pol...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Liebner R,Meyer M,Hey T,Winter G,Besheer A

    更新日期:2015-02-01 00:00:00

  • On the mechanism and dynamics of uptake and permeation of polyether-copolyester dendrimers across an in vitro blood-brain barrier model.

    abstract::Dendrimers have emerged as a promising drug delivery system due to their well defined size, tailorability, and multifunctional nature. However, their application in brain delivery is relatively a new area of research. The present study was aimed at evaluating the uptake and permeation of polyether-copolyester (PEPE) d...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Dhanikula RS,Hammady T,Hildgen P

    更新日期:2009-10-01 00:00:00

  • Imaging pharmaceutical tablets with optical coherence tomography.

    abstract::Optical coherence tomography (OCT) is a recently developed optical technique that produces depth profiles of three-dimensional objects. It is a nondestructive interferometric method responding to refractive index variation in the sample under study and can reach a penetration depth of a few millimetres. OCT employs ne...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Mauritz JM,Morrisby RS,Hutton RS,Legge CH,Kaminski CF

    更新日期:2010-01-01 00:00:00

  • Discontinuous oral absorption of cimetropium bromide, a new antispasmodic drug.

    abstract::The pharmacokinetic profiles of cimetropium bromide, after either intravenous injection of 10 mg or oral ingestion of 200 mg, were determined in eight healthy volunteers. After intravenous administration, the plasma levels and urinary excretion indicated that the drug is distributed and eliminated at a rapid rate (ter...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Imbimbo BP,Daniotti S,Vidi A,Foschi D,Saporiti F,Ferrante L

    更新日期:1986-07-01 00:00:00

  • New method for characterizing dissolution properties of drug powders.

    abstract::Various multiparticulate dissolution models that assume a log-normal particle-size distribution are fitted by nonlinear least-squares regression to data from the dissolution of micronized glyburide. Estimates of parameters describing the effective initial particle-size distribution are obtained, together with estimate...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Pedersen PV

    更新日期:1977-06-01 00:00:00

  • Pharmacokinetics of gentamicin in rabbits pretreated with nonsteroidal anti-inflammatory drugs: an interaction study.

    abstract::Interaction between nonsteroidal anti-inflammatory drugs (NSAIDs) and other drugs occurs relatively frequently because of the wide use of NSAIDs. Such interactions with drugs of narrow therapeutic index used in serious disease states may lead to toxicity. Gentamicin toxicity is based on its concentration in serum, and...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Shivprakash,Gandhi TP,Patel RB,Sheikh MA,Jhala A,Santani DD

    更新日期:1994-04-01 00:00:00

  • High-Throughput Melanin-Binding Affinity and In Silico Methods to Aid in the Prediction of Drug Exposure in Ocular Tissue.

    abstract::Drugs possessing the ability to bind to melanin-rich tissue, such as the eye, are linked with higher ocular exposure, and therefore have the potential to affect the efficacy and safety profiles of therapeutics. A high-throughput melanin chromatographic affinity assay has been developed and validated, which has allowed...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Reilly J,Williams SL,Forster CJ,Kansara V,End P,Serrano-Wu MH

    更新日期:2015-12-01 00:00:00

  • Comparison of granule strength and tablet tensile strength.

    abstract::The granule strength (crushing load) of lactose granulated with 1-9% povidone was measured initially and at intervals during a 1-year period. The granule strengths of dibasic calcium phosphate dihydrate granulated with various concentrations of starch and povidone were measured. The axial and radial tensile strengths ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Jarosz PJ,Parrott EL

    更新日期:1983-05-01 00:00:00

  • Expression of human polyspecific renal organic cation transport activity in Xenopus laevis oocytes.

    abstract::Polyspecific organic cation transporters in the basolateral and brush border membrane of the kidney play a role in the elimination of many clinically important drugs and endogenous compounds. In this study we report the functional expression of organic cation transport activity in Xenopus laevis oocytes injected with ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Chun JK,Piquette-Miller M,Zhang L,Giacomini KM

    更新日期:1997-06-01 00:00:00

  • Overall monotropic behavior of a metastable phase of biclotymol, 2,2'-methylenebis(4-chloro-3-methyl-isopropylphenol), inferred from experimental and topological construction of the related P-T state diagram.

    abstract::The melt from the usual monoclinic phase (Phase I) of biclotymol (T(fusI) = 400.5 +/- 1.0 K, Delta(fus)H(I) = 36.6 +/- 0.9 kJ mol(-1)) recrystallizes into another phase, Phase II, that melts at T(fusII) = 373.8 +/- 0.2 K (Delta(fus)H(II) = 28.8 +/- 1.0 kJ mol(-1)). The transformation of Phase II into Phase I is found ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Céolin R,Tamarit JL,Barrio M,López DO,Nicolaï B,Veglio N,Perrin MA,Espeau P

    更新日期:2008-09-01 00:00:00

  • Mathematical modeling and finite element simulation of slow release of drugs using hydrogels as carriers with various drug concentration distributions.

    abstract::In drug release systems using hydrogels as carriers, the presence of the polymer network will reduce the drug release rate, which can extend the release period. For a controlled-release process of drug, usually the ideal situation is to get a zero-order drug release rate. In this paper, the mathematical model of hydro...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Xu Y,Jia Y,Wang Z,Wang Z

    更新日期:2013-05-01 00:00:00

  • Autoxidation of tetrazepam in tablets: prediction of degradation impurities from the oxidative behavior in solution.

    abstract::The major route of degradation of tetrazepam (1) is oxidation to 7-chloro-5-(3-keto-cyclohexen-1-yl)-1,3-dihydro-1-methyl-2H-1, 4-benzodiazepin-2-one (3) via the stable 7-chloro-5-(3-hydroperoxy-cyclohexen-1-yl)-1,3-dihydro-1-methyl-2H -1, 4 benzodiazepin-2-one (2). Minor degradation products are 7-chloro-5-(1,2-epoxy...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Boccardi G,Deleuze C,Gachon M,Palmisano G,Vergnaud JP

    更新日期:1992-02-01 00:00:00

  • pH-Sensitive cationic copolymers of different macromolecular architecture as potential dexamethasone sodium phosphate delivery systems.

    abstract::This paper describes the synthesis and characterization of cationic copolymers with different macromolecular architecture and drug delivery properties of the corresponding dexamethasone sodium phosphate (DSP)-loaded systems. Copolyelectrolytes comprising poly[2-(acryloyloxy)ethyl] trimethylammonium chloride (PAETMAC) ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Georgieva D,Kostova B,Ivanova S,Rachev D,Tzankova V,Kondeva-Burdina M,Christova D

    更新日期:2014-08-01 00:00:00

  • Phosphorus-nitrogen compounds XIX: distribution of 32P and effect of an active oncolytic on intracerebral leukemia in rodents.

    abstract::P,P-Bis(1-aziridinyl)-N-1-adamantylphosphinic amide displayed oncolytic activity against intracerebral and intraperitoneal L-1210 leukemia. Administration of the isotope-labeled compound to rats shows 32P distribution to the brain. ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Cates LA,Cramer MB

    更新日期:1976-03-01 00:00:00

  • Indolizines II: search for potential oral hypoglycemic agents.

    abstract::A few 1,2-bis(N-alkylaminomethyl)indolizines, simple indolizinecarboxylic acids, and several 6-alkoxyindolizine-2-carboxylic acids were synthesized and screened as possible oral hypoglycemic agents. The absence of any significant hypoglycemic activity excludes these compounds from the predicted structural lead provide...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: De AU,Saha BP

    更新日期:1975-02-01 00:00:00

  • Serum lipid-lowering properties of 6-chloro-9-[2-(6-methyl-3-pyridyl)ethyl]-1,2,3,4-tetrahydrocarbazole-2-carboxylic acid.

    abstract::6-Chloro-9-[2-(6-methyl-3-pyridyl)ethyl]-1,2,3,4-tetrahydrocarbazole-2-carboxylic acid hydrochloride lowered serum cholesterol, triglyceride, phospholipid, and free fatty acid levels in normal rats. The compound appeared to have a low toxicity and to be well tolerated in mice, adult and neonatal rats, and rabbits. At ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Dalton C,Pool WR

    更新日期:1977-03-01 00:00:00