Abstract：
:The reaction of UICEL-A/102, a cellulose II powder recently prepared from Avicel(R) PH-102 by treatment with an aqueous sodium hydroxide solution, with glutaraldehyde in 0.01 N HCl has been investigated to improve its binder properties, without adversely affecting the rapid disintegration characteristic. The results showed that UICEL-A/102 and glutaraldehyde when reacted in a 1:0.6 weight ratio at 100 degrees C for 8.5 h produces a product, (hereinafter referred to as UICEL-XL), that, compared to UICEL-A/102, had a lower degree of polymerization, higher crystallinity, lower bulk density, lower tapped density, and higher porosity. Further, it showed lower yield pressure and higher crushing strength, and tensile strength values, indicating that UICEL-XL is more compressible and compactable than the starting material, UICEL-A/102. A comparison of "in-die" and "out-of-die" Heckel data indicated UICEL-XL to be less elastic than UICEL-A/102. Both UICEL-XL and UICEL-A/102 showed similar moisture sorption isotherms, and their compacts disintegrated rapidly in water. In conclusion, the glutaraldehyde-treated cellulose II powder not only serves as good a disintegrant as the untreated cellulose powder but also possesses superior binder properties.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
de la Luz Reus Medina M,Kumar Vdoi
10.1002/jps.20747subject
Has Abstractpub_date
2007-02-01 00:00:00pages
408-20issue
2eissn
0022-3549issn
1520-6017pii
S0022-3549(16)32188-8journal_volume
96pub_type
杂志文章abstract：:Corneal permeability data taken from the literature were analyzed for possible quantitative relationships with physicochemical properties. Although a parabolic relationship was obtained with good correlation between lipophilicity, as expressed by the 1-octanol-water partition coefficients, log Poctanol (or the distrib...
journal_title：Journal of pharmaceutical sciences
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doi：10.1021/js960484q
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journal_title：Journal of pharmaceutical sciences
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doi：10.1002/jps.2600670542
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journal_title：Journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.1002/jps.2600670543
更新日期：1978-05-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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doi：10.1002/jps.2600651127
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journal_title：Journal of pharmaceutical sciences
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