Abstract:
:(14)N nuclear quadrupole resonance (NQR) in two known polymorphs of famotidine was measured. At room temperature, seven quadrupolar sets of transition frequencies (ν(+), ν(-), and ν(0)) corresponding to seven different nitrogen sites in the crystal structure of each of the two polymorphs were found. This confirms the expected ability of NQR to distinguish polymorph B from its analog A. NQR can also measure their ratio in a solid mixture and in the final dosage form, that is, a tablet. The NQR frequencies, line shapes, and tentative assignation to all seven molecular (14)N atoms were obtained. Unravelment of these two entangled NQR spectra presents a valuable contribution to the NQR database and enables studies of some possible correlations therein. Moreover, nondestructive (14)N NQR studies of commercial famotidine tablets can reveal some details of the drug fabrication process connected with compression.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Luźnik J,Pirnat J,Jazbinšek V,Lavrič Z,Žagar V,Srčič S,Seliger J,Trontelj Zdoi
10.1002/jps.23956subject
Has Abstractpub_date
2014-09-01 00:00:00pages
2704-2709issue
9eissn
0022-3549issn
1520-6017pii
S0022-3549(15)30429-9journal_volume
103pub_type
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