Abstract:
:The kinetics of decomposition of the following conformationally restricted N-chloro-alpha-amino acids were studied: 1-amino-1-cyclopentanecarboxylic acid (2), 1-amino-1-cyclohexanecarboxylic acid (4), 2-amino-2-norbornanecarboxylic acid (6), and 2-amino-2-benzonorbornanecarboxylic acid (8). The first-order rate constants obtained were 0.520, 5.197, 0.198, and 0.078, respectively, which correlated with the ring strain in the structurally related cyclic ketones cyclopentanone, cyclohexanone, norborane-2-one, and benzonorbornane-2-one. The data are supportive of a concerted mechanism for the decomposition reaction involving an imine-like transition state.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Awad R,Hussain A,Crooks PAdoi
10.1002/jps.2600791216subject
Has Abstractpub_date
1990-12-01 00:00:00pages
1121-2issue
12eissn
0022-3549issn
1520-6017pii
S0022-3549(15)48432-1journal_volume
79pub_type
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