Buccal drug absorption. II: In vitro diffusion across the hamster cheek pouch.


:The in vitro diffusion of a series of substituted acetanilides across the hamster cheek pouch was studied. The keratinized epithelial layer of the cheek pouch appeared to provide the major barrier to diffusion of these compounds. Linear relationships were found for plots of log epithelial permeability (Pe) versus the log of the octanol-buffer partition coefficient (PCoct; r = 0.712), and log Pe versus the log of the isooctane-buffer partition coefficient (PCiso; r = 0.869). Comparison of the in vitro data with in vivo data obtained in humans using the buccal absorption test showed good correlation (r = 0.878) between Pe and percent buccal absorption in 5 min. These results suggest that diffusion across the hamster cheek pouch may have some utility in the prediction of human buccal absorption.


J Pharm Sci


Garren KW,Repta AJ




Has Abstract


1989-02-01 00:00:00














  • Elementary osmotic pump.

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Theeuwes F

    更新日期:1975-12-01 00:00:00

  • Phenytoin prodrugs VI: In vivo evaluation of a phosphate ester prodrug of phenytoin after parenteral administration to rats.

    abstract::Tissue damage caused by subcutaneous and intramuscular administration of three phenytoin prodrugs to rats was assessed. Since two of the prodrugs caused significant irritation, only 3-(hydroxymethyl)-5,5-diphenylhydantoin disodium phosphate ester might be useful as a nonirritant phenytoin prodrug suitable for parenter...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Varia SA,Stella VJ

    更新日期:1984-08-01 00:00:00

  • Effect of pH on the in vitro dissolution and in vivo absorption of controlled-release theophylline in dogs.

    abstract::Dogs were used to examine the effect of elevated gastric pH on the absorption of controlled-released theophylline dosage forms with pH-dependent dissolution. In vitro studies showed that a controlled-release theophylline tablet dissolved more rapidly if it was initially exposed to an acidic media. In contrast, a contr...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Vashi VI,Meyer MC

    更新日期:1988-09-01 00:00:00

  • Impurities in a morphine sulfate drug product identified as 5-(hydroxymethyl)-2-furfural, 10-hydroxymorphine and 10-oxomorphine.

    abstract::Stability testing of morphine sulfate formulated with nonpareil sugar seeds (consisting of sucrose and starch) and fumaric acid revealed the formation of the three impurities 5-(hydroxymethyl)-2-furfural, 10-hydroxymorphine and 10-oxomorphine. 5-(Hydroxymethyl)-2-furfural was isolated via semipreparative HPLC utilizin...

    journal_title:Journal of pharmaceutical sciences

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    authors: Kelly SS,Glynn PM,Madden SJ,Grayson DH

    更新日期:2003-03-01 00:00:00

  • Effects of organic anions on the uptake of 1-anilino-8-naphthalenesulfonate by isolated liver cells.

    abstract::Uptake of the fluorescent probe, 1-anilino-8-naphthalene-sulfonate (I) into isolated rat liver cells was studied using both fluorescence and filtration methods. The time course of the fluorescence enhancement of I after addition to the isolated liver cells was analyzed in terms of rapid, medium, and slow phases. The s...

    journal_title:Journal of pharmaceutical sciences

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    authors: Sugiyama Y,Kimura S,Lin JH,Izukura M,Awazu S,Hanano M

    更新日期:1983-08-01 00:00:00

  • Inclusion of acitretin into cyclodextrins: phase solubility, photostability, and physicochemical characterization.

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  • Biowaiver approach for biopharmaceutics classification system class 3 compound metformin hydrochloride using in silico modeling.

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    authors: Crison JR,Timmins P,Keung A,Upreti VV,Boulton DW,Scheer BJ

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    journal_title:Journal of pharmaceutical sciences

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    authors: Lévy MC,Rambourg P,Lévy J,Potron G

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  • Fluorescence assay of nitrofurantoin with o-aminothiophenol in plasma and urine.

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Watari N,Funaki T,Kaneniwa N

    更新日期:1980-01-01 00:00:00

  • Analysis of tricyclic antidepressants in human plasma by GLC--chemical-ionization mass spectrometry with selected ion monitoring.

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    journal_title:Journal of pharmaceutical sciences

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    authors: Jenkins RG,Friedel RO

    更新日期:1978-01-01 00:00:00

  • Synergistic effect of low-frequency ultrasound and sodium lauryl sulfate on transdermal transport.

    abstract::Application of low-frequency ultrasound has been shown to enhance transdermal transport of drugs (low-frequency sonophoresis). In this paper, we show that the efficacy of low-frequency ultrasound in enhancing transdermal transport can be further increased by its combination with sodium lauryl sulfate (SLS), a well-kno...

    journal_title:Journal of pharmaceutical sciences

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    authors: Mitragotri S,Ray D,Farrell J,Tang H,Yu B,Kost J,Blankschtein D,Langer R

    更新日期:2000-07-01 00:00:00

  • Apparent absorption kinetics of micronized griseofulvin after its oral administration on single- and multiple-dose regimens to rats as a corn oil-in-water emulsion and aqueous suspension.

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    journal_title:Journal of pharmaceutical sciences

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    authors: Bates TR,Carrigan PJ

    更新日期:1975-09-01 00:00:00

  • Developability assessment during the selection of novel therapeutic antibodies.

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    journal_title:Journal of pharmaceutical sciences

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    pub_type: 杂志文章


    authors: Wilcox RE,Humphrey DW,Riffee WH,Smith RV

    更新日期:1980-08-01 00:00:00

  • 5-( [aryl or aryloxy (or thio)]methyl)-3-(1H-imidazol-1-ylmethyl)-3- (2-thienyl)-2-methylisoxazolidine derivatives as novel antifungal agents.

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    journal_title:Journal of pharmaceutical sciences

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    authors: Mullen GB,Mitchell JT,Allen SD,St Georgiev V

    更新日期:1988-12-01 00:00:00

  • Physiologically Based Pharmacokinetic Modeling to Supplement Nilotinib Pharmacokinetics and Confirm Dose Selection in Pediatric Patients.

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    journal_title:Journal of pharmaceutical sciences

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    authors: Heimbach T,Lin W,Hourcade-Potelleret F,Tian X,Combes FP,Horvath N,He H

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  • A method to predict the equilibrium solubility of drugs in solid polymers near room temperature using thermal analysis.

    abstract::A method is presented for determining the equilibrium solubility of a drug in a solid polymer at or near room temperature, which represents a typical storage temperature. The method is based on a thermodynamic model to calculate the Gibbs energy change ΔG(SS) associated with forming a binary drug-polymer solid solutio...

    journal_title:Journal of pharmaceutical sciences

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    authors: Bellantone RA,Patel P,Sandhu H,Choi DS,Singhal D,Chokshi H,Malick AW,Shah N

    更新日期:2012-12-01 00:00:00

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    journal_title:Journal of pharmaceutical sciences

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    authors: Puri V,Dantuluri AK,Bansal AK

    更新日期:2011-06-01 00:00:00

  • Effect of powder substrate on foaml drainage and collapse: implications to foam granulation.

    abstract::Foam granulation is a relatively newer wet granulation process whereby foamed binder solutions are added to powders in a mixer. It is essential to understand the effect of powder substrate on foam drainage and half-life, which are relevant to nucleation and agglomeration during foam granulation. Hydroxypropyl methylce...

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    authors: Koo OM,Ji J,Li J

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    authors: Dhanikula RS,Hammady T,Hildgen P

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    abstract::During the drying process of a wet granulate, water-soluble compounds can migrate to the outer layers of the granule with the evaporating solvent. This migration can affect structural and mechanical characteristics of the granules as the solute accumulates on the granule's outer crust. The objective of this study was ...

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    authors: Poutiainen S,Honkanen M,Becker J,Nachtweide D,Järvinen K,Ketolainen J

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  • The relationship between "BET" and "free volume"-derived parameters for water vapor absorption into amorphous solids.

    abstract::Water vapor absorption isotherms for amorphous solids with the same chemical composition but differing in molecular weight (i.e., PVP-90, PVP-30, and PVP-12), and for glucose, trehalose, and two molecular weight grades of dextran were obtained at 30 degrees C and analyzed using the Brunauer-Emmett-Teller (BET) equatio...

    journal_title:Journal of pharmaceutical sciences

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    authors: Zhang J,Zografi G

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  • Interleukin-1 receptor antagonist: a new therapy for type 2 diabetes mellitus.

    abstract::Various complex mechanisms and their multifactorial pathways decisively provoke low-grade local and systemic inflammation in β-cells of pancreatic islets and peripheral tissues to induce β-cells' dysfunction and apoptosis, insulin resistance, and ultimately, overt type 2 diabetes mellitus (T2DM). Conventional antidiab...

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  • Kinetics of iron-mediated artemisinin degradation: effect of solvent composition and iron salt.

    abstract::The antimalarial endoperoxides, such as artemisinin, are postulated to exert their potent parasiticidal activity via the formation of reactive intermediates in the iron-rich infected erythrocyte. The in vitro chemical reaction profile of putative endoperoxide antimalarials and ferrous iron is often qualitatively used ...

    journal_title:Journal of pharmaceutical sciences

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    authors: Creek DJ,Chiu FC,Prankerd RJ,Charman SA,Charman WN

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    journal_title:Journal of pharmaceutical sciences

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    authors: Plise EG,Tran D,Salphati L

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    abstract::Recent in vitro and in vivo studies have suggested transscleral iontophoresis as a means for non-invasive drug delivery to the eye. However, there remains a lack of information of the iontophoretic transport behavior of the sclera. The objective of the present study was to investigate the effects of permeant concentra...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Li SK,Zhang Y,Zhu H,Higuchi WI,White HS

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  • Bioadhesive polymers as platforms for oral controlled drug delivery III: oral delivery of chlorothiazide using a bioadhesive polymer.

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Longer MA,Ch'ng HS,Robinson JR

    更新日期:1985-04-01 00:00:00

  • Uptake of acetazolamide by human erythrocytes in vitro.

    abstract::The binding of acetazolamide to human erythrocytes was studied in vitro. Blood and plasma samples were analyzed by electron-capture GLC. At 37 degrees, drug equilibrated between plasma and erythrocytes in approximately 40 min. The effect of plasma concentration on the steady-state level of drug within the erythrocytes...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Wallace SM,Reigelman S

    更新日期:1977-05-01 00:00:00

  • Unified model for the corneal permeability of related and diverse compounds with respect to their physicochemical properties.

    abstract::Corneal permeability data taken from the literature were analyzed for possible quantitative relationships with physicochemical properties. Although a parabolic relationship was obtained with good correlation between lipophilicity, as expressed by the 1-octanol-water partition coefficients, log Poctanol (or the distrib...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Yoshida F,Topliss JG

    更新日期:1996-08-01 00:00:00