Abstract:
:The effects of physical aging and antiplasticization on the water transport properties of glassy cellulose acetate film-coated tablets were investigated. The gradual approach toward thermodynamic equilibrium during physical aging decrease the free volume of the polymers. This decrease in free volume is accompanied by a decrease in the transport mobility, with concomitant changes in those properties of the polymer that depend on it. Antiplasticization arises from an interaction between the polymer and the plasticizer molecules and decreases the molecular mobility of the polymer and plasticizer. This effect was confirmed by mechanical measurements of polymer free films at the same experimental temperature. We have studied the additive effect of aging and antiplasticizing to see if the individual effects would interfere with one another, as might be expected if the same free volume were involved in each. The pronouncedly additive effects of physical aging and antiplasticization on the water permeability can be found in cellulose acetate film-coated tablets that were affected by longer physical aging time and lower plasticizer concentration. A theoretical study suggested that the free volume in the glassy polymer should consist of at least two independent parts, one of which is affected by annealing and the other by antiplasticization.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Guo JHdoi
10.1002/jps.2600830337subject
Has Abstractpub_date
1994-03-01 00:00:00pages
447-9issue
3eissn
0022-3549issn
1520-6017pii
S0022-3549(15)49385-2journal_volume
83pub_type
杂志文章abstract::The capacity factors of several penicillins and cephalosporins, as well as those of 7-aminocephalosporanic acid, 6-aminopenicillanic acid, and 7-aminodeacetoxycephalosporanic acid, were determined at pH 2.5-7.5 with different methanol concentrations in the mobile phase. The influence of ionic strength on activity fact...
journal_title:Journal of pharmaceutical sciences
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pub_type: 杂志文章,评审
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journal_title:Journal of pharmaceutical sciences
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journal_title:Journal of pharmaceutical sciences
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journal_title:Journal of pharmaceutical sciences
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更新日期:1984-11-01 00:00:00
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journal_title:Journal of pharmaceutical sciences
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doi:10.1002/jps.10000
更新日期:2002-01-01 00:00:00
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journal_title:Journal of pharmaceutical sciences
pub_type: 杂志文章
doi:10.1002/jps.2600680143
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journal_title:Journal of pharmaceutical sciences
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更新日期:1984-02-01 00:00:00
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更新日期:2006-08-01 00:00:00
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journal_title:Journal of pharmaceutical sciences
pub_type: 杂志文章
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更新日期:1993-11-01 00:00:00
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journal_title:Journal of pharmaceutical sciences
pub_type: 杂志文章
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更新日期:1989-10-01 00:00:00
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journal_title:Journal of pharmaceutical sciences
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更新日期:2013-01-01 00:00:00
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journal_title:Journal of pharmaceutical sciences
pub_type: 杂志文章
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更新日期:1976-01-01 00:00:00
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journal_title:Journal of pharmaceutical sciences
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journal_title:Journal of pharmaceutical sciences
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journal_title:Journal of pharmaceutical sciences
pub_type: 杂志文章
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