Abstract:
:The interaction between sulfadimethoxine and tolbutamide in sheep involving displacement from protein binding sites was investigated quantitatively. A 52% increase in the unbound plasma concentration of tolbutamide was observed in vitro at 37 degrees after the addition of sulfadimethoxine (100 microgram/ml) to sheep plasma containing tolbutamide (50 microgram/ml). Transient changes in tolbutamide's unbound and total plasma concentrations were noted after acute intravenous administration of sulfadimethoxine to sheep receiving a constant intravenous infusion of tolbutamide. These observations were consistent with displacement of tolbutamide from plasma and tissue binding sites and redistribution of the displaced tolbutamide into body water spaces. The steady state of both agents featured little change in the total plasma tolbutamide concentration, a 150% increase in the unbound plasma tolbutamide concentration, and an inhibition of tolbutamide oxidation by sulfadimethoxine. A model is presented and mathematical relationships are derived that permit a quantitation of the interaction and that indicate the sulfadimethoxine's constant of metabolic inhibition (K1) for tolbutamide metabolism is 65 microgram/ml.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Thiessen JJ,Rowland Mdoi
10.1002/jps.2600660803subject
Has Abstractpub_date
1977-08-01 00:00:00pages
1063-70issue
8eissn
0022-3549issn
1520-6017pii
S0022-3549(15)39496-Xjournal_volume
66pub_type
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journal_title:Journal of pharmaceutical sciences
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