Experimental evaluation of three single-particle dissolution models.

Abstract:

:The dissolution of the 60-85-mesh fraction os recording, flow-through dissolution apparatus equipped with a dissolution cell; it was particularly suitable for kinetic analysis of multiparticulate systems. By using a time-scaling approach, experimental data are compared with theoretical calculations to evaluate, quantitatively, which of three single-particle dissolution models best describes the data and how well the multiparticulate kinetics can be explained mathematically. The nonspherical tolbutamide particles are replaced in the calculations by a hypothetical system of spherical particles that appears to be log-normally distributed. This procedure permits the calculation of the intrinsic dissolution profile, considering both size distribution and particle shape effects.

journal_name

J Pharm Sci

authors

Pedersen PV,Brown KF

doi

10.1002/jps.2600651007

subject

Has Abstract

pub_date

1976-10-01 00:00:00

pages

1442-7

issue

10

eissn

0022-3549

issn

1520-6017

pii

S0022-3549(15)39008-0

journal_volume

65

pub_type

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