Abstract:
:The dissolution of the 60-85-mesh fraction os recording, flow-through dissolution apparatus equipped with a dissolution cell; it was particularly suitable for kinetic analysis of multiparticulate systems. By using a time-scaling approach, experimental data are compared with theoretical calculations to evaluate, quantitatively, which of three single-particle dissolution models best describes the data and how well the multiparticulate kinetics can be explained mathematically. The nonspherical tolbutamide particles are replaced in the calculations by a hypothetical system of spherical particles that appears to be log-normally distributed. This procedure permits the calculation of the intrinsic dissolution profile, considering both size distribution and particle shape effects.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Pedersen PV,Brown KFdoi
10.1002/jps.2600651007subject
Has Abstractpub_date
1976-10-01 00:00:00pages
1442-7issue
10eissn
0022-3549issn
1520-6017pii
S0022-3549(15)39008-0journal_volume
65pub_type
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journal_title:Journal of pharmaceutical sciences
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