Abstract:
:The degradation kinetics of gonadorelin were investigated systematically with reversed-phase high-performance liquid chromatography. The stability-indicating properties of this system were checked with photodiode array detection and by comparison with capillary zone electrophoretic analysis. Influences of gonadorelin concentration, pH, temperature, buffer ions, and ionic strength on the degradation kinetics were studied. The pH-log Kobs profile can be divided into three parts, a proton, a solvent, and a hydroxyl-catalyzed section, with different degradation products. These degradation products were characterized by mass using LC-MS. Gonadorelin is most stable at pH 5-5.5 with a half-life of 70 days at 70 degrees C. The overall degradation rate constant as a function of the temperature under acidic and alkaline conditions obeys the Arrhenius equation. The gonadorelin concentration and the concentrations of acetate, phosphate, borate, and carbonate buffer have no influence on the decomposition rate of the analyte. Increasing ionic strength led to higher Kobs at pH 2 and lower Kobs at pH 9, but influences were relatively small.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Hoitink MA,Beijnen JH,Bult A,van der Houwen OA,Nijholt J,Underberg WJdoi
10.1021/js9601187subject
Has Abstractpub_date
1996-10-01 00:00:00pages
1053-9issue
10eissn
0022-3549issn
1520-6017pii
S0022-3549(15)50153-6journal_volume
85pub_type
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