Abstract:
:The possibility tht metronidazole exerts several of its biological actions via interaction with important metal ions was investigated. NMR spectroscopy and polarography (ac) were used to test for any interaction, to locate the probable sites for complexation, and to determine the molecular stoichiometry of any complexes formed. Of the series of divalent metal ions tests, only cupric ion showed detectable interaction with metronidazole. The predominant site of interaction of cupric ion was the unsubstituted nitrogen atom (N-3) on the metronidazole molecule. The stoichiometry of the complex was (Cu-(metronidazole)4)+2. A likely structure for the complex is presented.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Chien YW,Lambert HJ,Sanvordeker DRdoi
10.1002/jps.2600640613subject
Has Abstractpub_date
1975-06-01 00:00:00pages
957-60issue
6eissn
0022-3549issn
1520-6017pii
S0022-3549(15)40267-9journal_volume
64pub_type
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