Abstract:
:The solubility of ergotamine tartrate in aqueous solutions of tartaric acid, citric acid, hydrochloric acid, and caffeine and the dissolution rate of ergotamine tartrate in aqueous mixtures containing hydrochloric acid, caffeine, citric acid, or sodium acetate were studied. The Noyes-Whitney model of dissolution is useful for predicting the dissolution rate of ergotamine tartrate in most of the dissolution media. The relative slowness with which ergotamine chloride (a substance with low water solubility) precipitated when ergotamine tartrate was dissolved in 0.1 M HCl resulted in the solid dissolving faster in this medium than was predicted using the Noyes-Whitney equation.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Anderson JR,Pitman IHdoi
10.1002/jps.2600690723subject
Has Abstractpub_date
1980-07-01 00:00:00pages
832-5issue
7eissn
0022-3549issn
1520-6017pii
S0022-3549(15)43315-5journal_volume
69pub_type
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