Abstract:
:Metronidazole and four derivatives were studied in vitro to investigate the differences in the extent of their binding to plasma proteins. Modification at the terminal portion of the alkyl side chain resulted in wide differences in the extent of binding. Molecular orbital calculations were performed by the CNDO and MINDO/2 methods to estimate the frontier electron density on the hetero atom at the 3'-position of the alkyl side chain. A linear correlation between the protein binding parameter (loge P) and the frontier electron density (qr) was observed for the binding of this group of trichomonicidal drugs. NMR spectroscopy was used to demonstrate that the alkyl side chain participated in the binding of these compounds to plasma proteins.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Sanvordeker DR,Chien YW,Lin TK,Lambert HJdoi
10.1002/jps.2600641111subject
Has Abstractpub_date
1975-11-01 00:00:00pages
1797-803issue
11eissn
0022-3549issn
1520-6017pii
S0022-3549(15)40513-1journal_volume
64pub_type
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