Abstract:
:Azo compounds are commonly used to study radical-mediated degradation of pharmaceutical compounds. The favorable chemical and physical properties of 2,2'-azobis(2-methylpropanenitrile) (AIBN) have made it one of the most widely used compound for these type of studies. This article describes the characterization of a stable product, N-(1-cyano-1-methylethyl)-2-methylpropanamide, formed during the decomposition of AIBN. This product is easily detected by liquid chromatography/mass spectrometry and can serve as a marker to confirm the AIBN is working as intended and to monitor the kinetic formation of free radical species.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Wells-Knecht KJ,Dunn Ddoi
10.1016/j.xphs.2019.05.012subject
Has Abstractpub_date
2019-09-01 00:00:00pages
3152-3155issue
9eissn
0022-3549issn
1520-6017pii
S0022-3549(19)30314-4journal_volume
108pub_type
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