Electron beam ionization mass fragmentographic analysis of tricyclic antidepressants in human plasma.

Abstract:

:A method for the measurement, in human plasma, of all tertiary and secondary tricyclic antidepressants prescribed in the United States is described. The method uses electron beam ionization GLC-mass spectrometry, employing a computer-controlled multiple-ion detector. This method, mass fragmentography, is used with internal standards for each drug. Plasma levels to as low as 10 ng/ml of the following drugs can be measured: amitriptyline, nortriptyline, doxepin, desmethyldoxepin, imipramine, desipramine, and protriptyline. Deuterium-labeled amitriptyline and imipramine are used as internal standards for those two drugs; for the other drugs, deuterated amitriptyline, nortriptyline, desmethyldoxepin, or desipramine is used. The method can measure up to 15 samples/hr, making it practical for large-scale studies of these drugs in patients. Spectra of each drug and examples of their analysis are given.

journal_name

J Pharm Sci

authors

Biggs JT,Holland WH,Chang S,Hipps PP,Sherman WR

doi

10.1002/jps.2600650221

subject

Has Abstract

pub_date

1976-02-01 00:00:00

pages

261-8

issue

2

eissn

0022-3549

issn

1520-6017

pii

S0022-3549(15)40616-1

journal_volume

65

pub_type

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