Abstract:
:Solubilization of nonpolar drugs constitutes one of the most important tasks in parenteral formulations design. This study investigates and assesses the solubility enhancement of Fluasterone by various techniques including cosolvency, micellization, and complexation. Of the solubilizing agents used, the modified beta-cyclodextrins were found to be the most effective. The solubility of Fluasterone is 1.55 x 10(-4) mM, 3.13 mM, and 4.04 mM in water, 20% sulfobutyl ether-beta-cyclodextrin (SBEbetaCD), and 20% hydroxypropyl-beta-cyclodextrin (HPbetaCD), respectively.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Zhao L,Li P,Yalkowsky SHdoi
10.1021/js9901413subject
Has Abstractpub_date
1999-10-01 00:00:00pages
967-9issue
10eissn
0022-3549issn
1520-6017pii
S0022-3549(15)50885-Xjournal_volume
88pub_type
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