Abstract:
:Levemopamil was solubilized by varying the concentration of hydroxypropyl-beta-cyclodextrin (HPbetaCD) and by the alteration of pH. The drug molecule has two sites for possible complexation with HPbetaCD, creating the possibility of either 1:1 or 1:2 complexation. The solubility as a function of HPbetaCD concentration of the charged and uncharged forms of the drug follows the A(L) and Ap complexation models, respectively. This suggests that the charged drug forms a 1:1 complex, whereas the neutral drug forms both 1:1 and 1:2 complexes.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
McCandless R,Yalkowsky SHdoi
10.1021/js9802143subject
Has Abstractpub_date
1998-12-01 00:00:00pages
1639-42issue
12eissn
0022-3549issn
1520-6017pii
S0022-3549(15)50698-9journal_volume
87pub_type
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