Abstract：
:Dissolution profiles are classified in accordance with the shape of fractional dissolution rate function. This function is constant in time for the classical first-order model and, in this case, the dissolution is described by a monoexponential function. Therefore, any deviation of the fractional dissolution rate from the constant level suggests the presence of different (nonlinear/nonhomogenous) mechanisms in the dissolution process. The shapes of the fractional dissolution rate depend on the type of the model of dissolution; thus, classification with respect to this function is proposed as a tool for model selection. The Kullback-Leibler information distance is proposed for measuring similarity between two different drug dissolution profiles. The method is applied mainly to compare the first-order model, which characterizes a homogenous dosage form, with other common descriptors of dissolution and with experimental data.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Lánský P,Weiss Mdoi
10.1002/jps.10419subject
Has Abstractpub_date
2003-08-01 00:00:00pages
1632-47issue
8eissn
0022-3549issn
1520-6017pii
S0022-3549(16)31302-8journal_volume
92pub_type
杂志文章abstract：:Three series of 3,4,5-trisubstituted pyrazolesulfonylurea derivatives were prepared and evaluated as hypoglycemic agents. Preliminary biological testing revealed that the new compounds possess moderate hypoglycemic activity. ...
journal_title：Journal of pharmaceutical sciences
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abstract：:Emerging 3D printing technologies offer an exciting opportunity to create customized 3D objects additively from a digital design file. 3D printing may be further leveraged for personalized medicine, clinical trial, and controlled release applications. A wide variety of 3D printing methods exists, and many studies focu...
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abstract：:15-Lipoxygenase (15-LOX) is one of the key enzymes responsible for the formation of oxidized low-density lipoprotein, a major causal factor for atherosclerosis. Δ(9)-Tetrahydrocannabinol (Δ(9)-THC), a major component of marijuana, has suggested to suppress atherosclerosis. Although Δ(9)-THC seems to be attractive for ...
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doi：10.1021/js970342b
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abstract：:Modified cyclodextrins (CDs) have shown great promise as non-viral gene and siRNA delivery vectors in a range of in vitro and in vivo studies. In the current study, structural and biophysical characterisation of selected CDs was carried out to enhance our understanding of their interaction with nucleic acids. The meth...
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journal_title：Journal of pharmaceutical sciences
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journal_title：Journal of pharmaceutical sciences
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journal_title：Journal of pharmaceutical sciences
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journal_title：Journal of pharmaceutical sciences
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doi：10.1016/j.xphs.2016.04.002
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journal_title：Journal of pharmaceutical sciences
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doi：10.1002/jps.24585
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journal_title：Journal of pharmaceutical sciences
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更新日期：2012-05-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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journal_title：Journal of pharmaceutical sciences
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doi：10.1002/jps.22082
更新日期：2010-07-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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journal_title：Journal of pharmaceutical sciences
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journal_title：Journal of pharmaceutical sciences
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更新日期：1996-02-01 00:00:00
