Rapid GLC determination of fusaric acid in biological fluids.

Abstract:

:A simple, sensitive GLC assay was developed for fusaric acid, the active metabolite of bupicomide, to follow the disposition of this investigational antihypertensive agent in patients undergoing therapy. Fusaric acid is efficiently extracted from biological samples, derivatized by on-column methylation, and chromatographed using flame-ionization detection. An internal standard is utilized to quantitate results. The procedure is rapid and specific for fusaric acid, and has a lower limit of sensitivity of 0.1 mug/ml. The method is suitable for supporting pharmacokinetic studies of bupicomide following therapeutic doses in animals and humans.

journal_name

J Pharm Sci

authors

Fung KK,Koda RT,Maronde RF,Cohen JL

doi

10.1002/jps.2600650430

subject

Has Abstract

pub_date

1976-04-01 00:00:00

pages

596-08

issue

4

eissn

0022-3549

issn

1520-6017

pii

S0022-3549(15)40728-2

journal_volume

65

pub_type

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