Rapid GLC determination of fusaric acid in biological fluids.


:A simple, sensitive GLC assay was developed for fusaric acid, the active metabolite of bupicomide, to follow the disposition of this investigational antihypertensive agent in patients undergoing therapy. Fusaric acid is efficiently extracted from biological samples, derivatized by on-column methylation, and chromatographed using flame-ionization detection. An internal standard is utilized to quantitate results. The procedure is rapid and specific for fusaric acid, and has a lower limit of sensitivity of 0.1 mug/ml. The method is suitable for supporting pharmacokinetic studies of bupicomide following therapeutic doses in animals and humans.


J Pharm Sci


Fung KK,Koda RT,Maronde RF,Cohen JL




Has Abstract


1976-04-01 00:00:00














  • Particle shape: a new design parameter for passive targeting in splenotropic drug delivery.

    abstract::The role of particle size and surface modification on biodistribution of nanocarriers is widely reported. We report for the first time the role of nanoparticle shape on biodistribution. Our study demonstrates that irregular shaped polymer lipid nanoparticles (LIPOMER) evade kupffer cells and localize in the spleen. We...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Devarajan PV,Jindal AB,Patil RR,Mulla F,Gaikwad RV,Samad A

    更新日期:2010-06-01 00:00:00

  • Influence of race or ethnicity on pharmacokinetics of drugs.

    abstract::Review of the current literature on racial differences in pharmacokinetics of drugs supports the premise that only pharmacokinetic processes which are biologically or biochemically mediated have the potential to exhibit differences between racial or ethnic groups. Thus, the pharmacokinetic factors which can be expecte...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章,评审


    authors: Johnson JA

    更新日期:1997-12-01 00:00:00

  • Bioadhesive polymers as platforms for oral controlled drug delivery III: oral delivery of chlorothiazide using a bioadhesive polymer.

    abstract::Bioadhesive polymers that bind to the gastric mucin or epithelial cell surface are useful in drug delivery for the purposes of (a) retaining a dosage from in the GI tract and (b) increasing the intimacy and duration of contact of drug with the absorbing membrane. Polycarbophil has previously been shown to have bioadhe...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Longer MA,Ch'ng HS,Robinson JR

    更新日期:1985-04-01 00:00:00

  • pH indicator titration: a novel fast pKa determination method.

    abstract::This study describes a fast spectrophotometic titration method for apparent ionization constant (pKa) determination. In this method, a Universal pH indicator is utilized instead of the conventional pH electrode. An autoburette is set to add HCl at a constant rate to a vigorously stirred 1 cm UV cuvette which contains ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Kong X,Zhou T,Liu Z,Hider RC

    更新日期:2007-10-01 00:00:00

  • Polymorphism and solvatomorphism 2007.

    abstract::Papers and patents that deal with polymorphism (crystal systems for which a substance can exist in structures characterized by different unit cells, but where each of the forms has exactly the same elemental composition) and solvatomorphism (systems where the crystal structures of the substance are defined by differen...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章,评审


    authors: Brittain HG

    更新日期:2009-05-01 00:00:00

  • In the search for new anticancer drugs. 28. Synthesis and evaluation of highly active aminoxyl labeled amino acid derivatives containing the [N'-(2-chloroethyl)-N'-nitrosoamino]carbonyl group.

    abstract::The aminoxyl (nitroxyl) labeled (2-chloroethyl)nitrosocarbamoyl (CNC) derivatives of amino acids, i.e., N-[[N'-(2-chloroethyl)-N'-nitrosoamino]carbonyl]-A-(1-oxy-2,2,6,6- tetramethylpiperidin-4-yl)amides, A = glycyl (10a), A = L-alanyl (10b), A = L-valyl (10c), A = L-phenylalanyl (10d), were synthesized and evaluated ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Sosnovsky G,Baysal M,Erciyas E

    更新日期:1994-07-01 00:00:00

  • Antitumor efficacy of taxane liposomes on a human ovarian tumor xenograft in nude athymic mice.

    abstract::Taxanes such as paclitaxel (Taxol) and docetaxel (Taxotere) are promising agents for use against ovarian cancer and other malignancies. Recently, SB-T-1011, a semisynthetic taxane, has been prepared from 14-hydroxy-10-deacetylbaccatin III. SB-T-1011 shows similar or greater in vitro cytostatic activity than paclitaxel...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Sharma A,Straubinger RM,Ojima I,Bernacki RJ

    更新日期:1995-12-01 00:00:00

  • PEGylated interferon displays differences in plasma clearance and bioavailability between male and female mice and between female immunocompetent C57Bl/6J and athymic nude mice.

    abstract::Gender and immune status can considerably impact on the pharmacokinetics (PK) of macromolecular and small molecule drugs. However, these effects are often not considered in drug development. We aimed to quantitatively evaluate effects of gender and immune status on the PK of PEGylated interferon in frequently used mur...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Landersdorfer CB,Caliph SM,Shackleford DM,Ascher DB,Kaminskas LM

    更新日期:2015-05-01 00:00:00

  • Optimization of sample preparation conditions for detecting trace amounts of β-tegafur in α- and β-tegafur mixture.

    abstract::We report a semiquantitative method for determining trace amounts (<1%) of thermodynamically stable forms in polymorphic mixtures, focusing on sample preparation effects on solid phase transitions. Tegafur [5-fluoro-1-(oxolan-2-yl)-1,2,3,4-tetrahydropyrimidine-2,4-dione] was used as a model material in this study. The...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Bobrovs R,Actiņš A

    更新日期:2012-12-01 00:00:00

  • Understanding Subcutaneous Tissue Pressure for Engineering Injection Devices for Large-Volume Protein Delivery.

    abstract::Subcutaneous injection allows for self-administration of monoclonal antibodies using prefilled syringes, autoinjectors, and on-body injector devices. However, subcutaneous injections are typically limited to 1 mL due to concerns of injection pain from volume, viscosity, and formulation characteristics. Back pressure c...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Doughty DV,Clawson CZ,Lambert W,Subramony JA

    更新日期:2016-07-01 00:00:00

  • Dissolution profiles for finely divided drug suspensions.

    abstract::A suspension of micronized prednisolone acetate was separated into four fractions by the technique of centrifugal elutriation. Data showed that each fraction had a narrow particle size. The dissolution experiments were carried out under sink conditions (less than 10% of saturation concentration) in a dissolution appar...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Mauger JW,Howard SA,Amin K

    更新日期:1983-02-01 00:00:00

  • Dielectric properties of pharmaceutical materials relevant to microwave processing: effects of field frequency, material density, and moisture content.

    abstract::The rising popularity of microwaves for drying, material processing and quality sensing has fuelled the need for knowledge concerning dielectric properties of common pharmaceutical materials. This article represents one of the few reports on the density and moisture content dependence of the dielectric properties of p...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Heng PW,Loh ZH,Liew CV,Lee CC

    更新日期:2010-02-01 00:00:00

  • High-performance liquid chromatographic determination of (Z)- and (E)-doxepin hydrochloride isomers.

    abstract::A high-performance liquid chromatographic method for the determination of (Z)- and (E)-doxepin hydrochloride isomers was developed. The analysis employs a column packed with spherical silica microparticles (5-6 mum), and a mobile phase of acetonitrile-chloroform-diethylamine (750:250:0.2) permits baseline resolution a...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Whall TJ,Dokladalova J

    更新日期:1979-11-01 00:00:00

  • Kinetics and stability of a multicomponent organophosphate antidote formulation in glass and plastic.

    abstract::An aqueous solution of trimedoxime bromide, atropine, and benactyzine hydrochloride was formulated to have maximum stability as an antidote in organophosphorus poisoning. The stability of the mixture in glass and plastic cartridges was determined. Glass cartridges were more desirable than plastic; there was less vapor...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Zvirblis P,Ellin RI

    更新日期:1982-03-01 00:00:00

  • Diphenhydramine disposition in the sheep maternal-placental-fetal unit: determinants of plasma drug concentrations in the mother and the fetus.

    abstract::The objective of this study was to identify the important factors that determine plasma concentrations of diphenhydramine (DPHM) in the mother and the fetus after maternal as well as fetal steady-state drug administration. Inter-relationships were evaluated between maternal and fetal placental and nonplacental clearan...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Kumar S,Tonn GR,Riggs KW,Rurak DW

    更新日期:1999-12-01 00:00:00

  • Carrier-Mediated Transport of Nicotine Across the Inner Blood-Retinal Barrier: Involvement of a Novel Organic Cation Transporter Driven by an Outward H(+) Gradient.

    abstract::The present study was carried out to investigate the blood-to-retina transport of nicotine across the inner blood-retinal barrier (BRB). Using the in vivo vascular injection method, the blood-to-retina influx clearance of nicotine across the BRB was determined as 131 μL/(min?g retina), which is much higher than that o...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Tega Y,Kubo Y,Yuzurihara C,Akanuma S,Hosoya K

    更新日期:2015-09-01 00:00:00

  • Ocular absorption behavior of palmitoyl tilisolol, an amphiphilic prodrug of tilisolol, for ocular drug delivery.

    abstract::The objective of this study was to examine the ocular absorption behavior of an amphiphilic prodrug after instillation onto the cornea of rabbits. A micellar solution of O-palmitoyl tilisolol (PalTL), an amphiphilic prodrug, was prepared. After instillation of tilisolol (TL) and PalTL, the drug concentrations in the t...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Kawakami S,Nishida K,Mukai T,Yamamura K,Kobayashi K,Sakaeda T,Nakamura J,Nakashima M,Sasaki H

    更新日期:2001-12-01 00:00:00

  • Kinetics of drug-drug interactions in sheep: tolbutamide and sulfadimethoxine.

    abstract::The interaction between sulfadimethoxine and tolbutamide in sheep involving displacement from protein binding sites was investigated quantitatively. A 52% increase in the unbound plasma concentration of tolbutamide was observed in vitro at 37 degrees after the addition of sulfadimethoxine (100 microgram/ml) to sheep p...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Thiessen JJ,Rowland M

    更新日期:1977-08-01 00:00:00

  • Differentiation of organ availability by sequential and simultaneous analyses: intestinal conjugative metabolism impacts on intestinal availability in humans.

    abstract::The impact of intestinal conjugative metabolism on oral bioavailability was assessed by sequential and simultaneous analyses of the reported data in humans. The data were retrieved from reports on drugs that are metabolized by sulfate conjugation, and the organ availabilities affecting oral bioavailability were differ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Mizuma T,Kawashima K,Sakai S,Sakaguchi S,Hayashi M

    更新日期:2005-03-01 00:00:00

  • Optimizing a Novel Au-Grafted Lipid Nanoparticle Through Chelation Chemistry for High Photothermal Biologic Activity.

    abstract::Gold nanoparticles through nucleation of Au clusters have been extensively studied. However, due to low potency, prolonged tissue retention, and irreversible accumulation, the safety considerations have limited their therapeutic and diagnostic applications. Novel gold nanostructures with retained physical properties a...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Gao Y,Mu Q,Zhu L,Li Z,Ho RJY

    更新日期:2020-05-01 00:00:00

  • Container Surfaces Control Initiation of Cavitation and Resulting Particle Formation in Protein Formulations After Application of Mechanical Shock.

    abstract::Mechanical shock may cause cavitation in vials containing liquid formulations of therapeutic proteins and generate protein aggregates and other particulates. To test whether common formulation components such as protein molecules, air bubbles, or polysorbate 20 (PS20) micelles might nucleate cavitation, a high-speed v...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Wu H,Chisholm CF,Puryear M,Movafaghi S,Smith SD,Pokhilchuk Y,Lengsfeld CS,Randolph TW

    更新日期:2020-03-01 00:00:00

  • Cholesterol-mediated activation of P-glycoprotein: distinct effects on basal and drug-induced ATPase activities.

    abstract::Cholesterol promotes basal and verapamil-induced ATPase activity of P-glycoprotein (P-gp). We investigated whether these effects are related to each other and to the impact of the sterol on bilayer fluidity and verapamil membrane affinity. P-gp was reconstituted in egg-phosphatidylcholine (PhC) liposomes with or witho...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Belli S,Elsener PM,Wunderli-Allenspach H,Krämer SD

    更新日期:2009-05-01 00:00:00

  • Electromigration of ions across the skin: determination and prediction of transport numbers.

    abstract::In iontophoresis, an electric field across the skin induces electromigration of exogenously applied and endogenously present ions. The approach can be used to improve dramatically drug delivery by elimination of competing co-ions in the externally applied formulation, as this maximizes the fraction of current carried ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Mudry B,Guy RH,Delgado-Charro MB

    更新日期:2006-03-01 00:00:00

  • Plasma binding of benzodiazepines in humans.

    abstract::Plasma binding of chlordiazepoxide, diazepam, loraxepam, and oxazepam was determined by equilibrium dialysis in 20 male, healthy volunteers, 25-86 years old. A wide range of binding was observed, with the free fraction varying twofold for lorazepam, fourfold for chlordiazepoxide and diazepam, and over 20-fold for oxa...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Johnson RF,Schenker S,Roberts RK,Desmond PV,Wilkinson GR

    更新日期:1979-10-01 00:00:00

  • pH-Sensitive cationic copolymers of different macromolecular architecture as potential dexamethasone sodium phosphate delivery systems.

    abstract::This paper describes the synthesis and characterization of cationic copolymers with different macromolecular architecture and drug delivery properties of the corresponding dexamethasone sodium phosphate (DSP)-loaded systems. Copolyelectrolytes comprising poly[2-(acryloyloxy)ethyl] trimethylammonium chloride (PAETMAC) ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Georgieva D,Kostova B,Ivanova S,Rachev D,Tzankova V,Kondeva-Burdina M,Christova D

    更新日期:2014-08-01 00:00:00

  • Development of budesonide nanocluster dry powder aerosols: processing.

    abstract::Aerosolized medicine is one of the fastest growing areas in the pharmaceutical industry. Dry powder aerosols of pharmaceutical compounds are particularly attractive for the prevention and treatment of respiratory diseases but are also emerging as a treatment option for systemic diseases. Engineering particles in dry p...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: El-Gendy N,Selvam P,Soni P,Berkland C

    更新日期:2012-09-01 00:00:00

  • Sustained release of ferrous sulfate from polymer-coated gum arabica pellets.

    abstract::Sustained release of ferrous sulfate (FeSO4) from gum arabica pellets has been achieved for 7 h. Release is further sustained for 12 to 600 h by coating the pellets with polyvinyl acetate and ethylene vinyl acetate, respectively. An increase in the amount of gum arabica in the pellets decreases the rate of release due...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Batra V,Bhowmick A,Behera BK,Ray AR

    更新日期:1994-05-01 00:00:00

  • Biowaiver monographs for immediate release solid oral dosage forms: metronidazole.

    abstract::Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing metronidazole are reviewed. Metronidazole can be assigned to Biopharmaceutics Classification System Class I. Most BE studies that were identifi...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Rediguieri CF,Porta V,G Nunes DS,Nunes TM,Junginger HE,Kopp S,Midha KK,Shah VP,Stavchansky S,Dressman JB,Barends DM

    更新日期:2011-05-01 00:00:00

  • Rapid colorimetric analysis of chlorhexidine in pharmaceutical preparations.

    abstract::A colorimetric determination of chlorhexidine is described. The method is based on the formation of a yellow complex between the drug and bromcresol green. The absorption peak of this complex, extracted by chloroform, is at 410 nm, and linear response is obtained from 2.5 to 30 micrograms of chlorhexidine/ml. The accu...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Andermann G,Buhler MO,Erhart M

    更新日期:1980-02-01 00:00:00

  • Pharmacokinetics of oral cephalosporins: cephradine cephalexin.

    abstract::A crossover experiment was utilized to compare the pharmacokinetics of a 1-g dose of cephalexin tablets, cephalexin capsules, or cephradine capsules in nine normal human volunteers. These antibiotics were administered as three formulations: two 500-mg capsulin every 6 hr for five doses, and one 1000-mg tablet of cepha...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Finkelstein E,Quintiliani R,Lee R,Bracci A,Nightingale CH

    更新日期:1978-10-01 00:00:00