Abstract：
:In this paper we describe how the spherical crystallization process by QESD method can be applied to a water-soluble drug, salbutamol sulfate. The type of solvent, antisolvent, and emulsifier and the concentration of emulsifier to be used for the production of spherical particles with a size range 80-500 microm are determined. Furthermore, the solvent/antisolvent ratio and the temperature difference between them (Delta T) are studied. It was observed that, in the case of salbutamol sulfate, the Delta T value has no influence on the formation of spherical particles. A very large metastable zone of salbutamol sulfate in water could explain this phenomenon. Finally, the influence of emulsifier concentration and of maturation time on the size of spherical particles is studied. The results show that these two parameters must be fixed to control the size of the recovered particles.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Nocent M,Bertocchi L,Espitalier F,Baron M,Couarraze Gdoi
10.1002/jps.1112subject
Has Abstractpub_date
2001-10-01 00:00:00pages
1620-7issue
10eissn
0022-3549issn
1520-6017pii
S0022-3549(16)30843-7journal_volume
90pub_type
杂志文章abstract：:The correlation between dynamic surface properties of drug molecules and drug absorption in two common in vitro models of the intestinal wall (Caco-2 monolayers and rat intestinal segments) has been investigated. A homologous series of beta-adrenoreceptor antagonists were used as model compounds. Dynamic molecular sur...
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abstract：:In previous studies (Yoneto et al., 1995. J Pharm Sci 84:312-317; Kim et al., 1992. Int J Pharm 80:17-31; and Warner et al., 2001. J Pharm Sci 90:1143-53), the transport enhancing effects of four homologous series of enhancers-the n-alkanols, 1-alkyl-2-pyrrolidones, 1,2-alkanediols, and N,N-dimethylalkanamides - on th...
journal_title：Journal of pharmaceutical sciences
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doi：10.1002/jps.1059
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doi：10.1002/jps.20959
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journal_title：Journal of pharmaceutical sciences
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doi：10.1002/jps.2600730840
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journal_title：Journal of pharmaceutical sciences
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journal_title：Journal of pharmaceutical sciences
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