Abstract:
:A high-performance liquid chromatographic method for the determination of (Z)- and (E)-doxepin hydrochloride isomers was developed. The analysis employs a column packed with spherical silica microparticles (5-6 mum), and a mobile phase of acetonitrile-chloroform-diethylamine (750:250:0.2) permits baseline resolution and simultaneous determination of the (Z)- and (E)-doxepin isomers. Process-related substances do not interfere. The method is accurate and precise (the relative standard deviation was 0.3% for both isomers). The simple procedure is highly suitable for routine doxepin hydrochloride analysis.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Whall TJ,Dokladalova Jdoi
10.1002/jps.2600681133subject
Has Abstractpub_date
1979-11-01 00:00:00pages
1454-6issue
11eissn
0022-3549issn
1520-6017pii
S0022-3549(15)42934-Xjournal_volume
68pub_type
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