当前位置： SCI文献检索 > JOURNAL OF PHARMACEUTICAL SCIENCES期刊下所有文献 > Population Pharmacokinetics of Doripenem in Pediatric Patients and Monte-Carlo Pharmacokinetic-Pharmacodynamic Simulations for Dosing Regimen Assessment.

Population Pharmacokinetics of Doripenem in Pediatric Patients and Monte-Carlo Pharmacokinetic-Pharmacodynamic Simulations for Dosing Regimen Assessment.

Abstract：

:The aims of this study were to evaluate the pharmacokinetics of doripenem (Finibax®, Doribax®, S-4661), a parenteral carbapenem antibiotic, in pediatric patients based on concentrations of doripenem in plasma after administration of 20 mg/kg 2 or 3 times daily and to evaluate the dosing regimens by using Monte-Carlo pharmacokinetic-pharmacodynamic simulations. Population pharmacokinetic analysis was performed by using 190 plasma concentrations of doripenem from 99 patients (2 months-13 years old). The two-compartment model well described the doripenem plasma concentrations in pediatric patients. Body weight was found to be the most significant influential factor. Gender was also found to be a significant covariate although the effect was relatively small. Monte-Carlo simulations indicated that 20 mg/kg over 1 h infusion would give 90% probability of target attainment for 40% of time above minimum inhibitory concentration against Haemophilus influenzae and Streptococcus pneumoniae, major causative pathogens in pediatric infections, and that 40 mg/kg, the highest approved dose for Japanese pediatric patients, administered over 3 h infusion achieved 98.6% against 8 μg/mL. The developed population pharmacokinetic model of doripenem and Monte-Carlo simulations for pediatric patients should provide useful information for understanding the pharmacokinetic and pharmacokinetic-pharmacodynamic characteristics of doripenem and for optimal treatment of pediatric patients.

journal_name

J Pharm Sci

journal_title

Journal of pharmaceutical sciences

authors

Matsuo Y,Ishibashi T,Matsumoto S,Katsube T,Wajima T

doi

10.1016/j.xphs.2019.04.002

subject

Has Abstract

pub_date

2019-09-01 00:00:00

pages

3099-3105

issue

9

eissn

0022-3549

issn

1520-6017

pii

S0022-3549(19)30225-4

journal_volume

108

pub_type

杂志文章

相关文献

JOURNAL OF PHARMACEUTICAL SCIENCES文献大全
  • Chemical modifications of therapeutic proteins induced by residual ethylene oxide.

    abstract：:Ethylene oxide (EtO) is widely used in sterilization of drug product primary containers and medical devices. The impact of residual EtO on protein therapeutics is of significant interest in the biopharmaceutical industry. The potential for EtO to modify individual amino acids in proteins has been previously reported. ...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1002/jps.24257

    authors： Chen L,Sloey C,Zhang Z,Bondarenko PV,Kim H,Ren D,Kanapuram S

    更新日期：2015-02-01 00:00:00

  • Vacuum-Induced Surface Freezing for the Freeze-Drying of the Human Growth Hormone: How Does Nucleation Control Affect Protein Stability?

    abstract：:In the present work, the effect of controlled nucleation on the stability of human growth hormone (hGH) during freeze-drying has been investigated. More specifically, the vacuum-induced surface freezing technique has been compared to conventional freezing, both with and without an annealing step. Size exclusion chroma...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1016/j.xphs.2019.04.014

    authors： Oddone I,Arsiccio A,Duru C,Malik K,Ferguson J,Pisano R,Matejtschuk P

    更新日期：2020-01-01 00:00:00

  • Achieving continuous manufacturing for final dosage formation: challenges and how to meet them. May 20-21, 2014 Continuous Manufacturing Symposium.

    abstract：:We describe the key issues and possibilities for continuous final dosage formation, otherwise known as downstream processing or drug product manufacturing. A distinction is made between heterogeneous processing and homogeneous processing, the latter of which is expected to add more value to continuous manufacturing. W...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章,评审

    doi：10.1002/jps.24247

    authors： Byrn S,Futran M,Thomas H,Jayjock E,Maron N,Meyer RF,Myerson AS,Thien MP,Trout BL

    更新日期：2015-03-01 00:00:00

  • Mannitol/l-Arginine-Based Formulation Systems for Freeze Drying of Protein Pharmaceuticals: Effect of the l-Arginine Counter Ion and Formulation Composition on the Formulation Properties and the Physical State of Mannitol.

    abstract：:Previous studies have shown that protein storage stability in freeze-dried l-arginine-based systems improved in the presence of chloride ions. However, chloride ions reduced the glass transition temperature of the freeze concentrate (Tg') and made freeze drying more challenging. In this study, l-arginine was freeze dr...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1016/j.xphs.2016.07.001

    authors： Stärtzel P,Gieseler H,Gieseler M,Abdul-Fattah AM,Adler M,Mahler HC,Goldbach P

    更新日期：2016-10-01 00:00:00

  • Infrared spectroscopic studies of lyophilization- and temperature-induced protein aggregation.

    abstract：:Recent studies have clearly demonstrated that Fourier transform IR spectroscopy can be a powerful tool for the study of protein stabilization during freeze-drying and for optimizing approaches to prevent lyophilization-induced protein aggregation. The purpose of the current review is to provide an overview of these to...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1002/jps.2600840407

    authors： Dong A,Prestrelski SJ,Allison SD,Carpenter JF

    更新日期：1995-04-01 00:00:00

  • Development of aqueous parenteral formulations for carbamazepine through the use of modified cyclodextrins.

    abstract：:The poor aqueous solubility of carbamazepine was dramatically increased via complexation with various chemically modified beta-cyclodextrins and gamma-cyclodextrins. A preparation of carbamazepine and 2-hydroxypropyl-beta-cyclodextrin was found to be stable to steam sterilization and to storage under a variety of cond...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1002/jps.2600800420

    authors： Brewster ME,Anderson WR,Estes KS,Bodor N

    更新日期：1991-04-01 00:00:00

  • Lyophilization Process Design and Development: A Single-Step Drying Approach.

    abstract：:High-throughput lyophilization process was designed and developed for protein formulations using a single-step drying approach at a shelf temperature (Ts) of ≥40°C. Model proteins were evaluated at different protein concentrations in amorphous-only and amorphous-crystalline formulations. Single-step drying resulted in...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1016/j.xphs.2018.11.021

    authors： Pansare SK,Patel SM

    更新日期：2019-04-01 00:00:00

  • The Use of Binary Polymeric Networks in Stabilizing Polyethylene Oxide Solid Dispersions.

    abstract：:The objective of this study was to determine if a high Tg polymer (Eudragit(®) S100) could be used to stabilize amorphous domains of polyethylene oxide (PEO) and hence improve the stability of binary polymer systems containing celecoxib (CX). We propose a novel method of stabilizing the amorphous PEO solid dispersion ...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1016/j.xphs.2016.06.004

    authors： Jones DS,Tian Y,Li S,Yu T,Abu-Diak OA,Andrews GP

    更新日期：2016-10-01 00:00:00

  • Quantifying errors in tableting data analysis using the Ryshkewitch equation due to inaccurate true density.

    abstract：:Although inaccurate true density affects analysis of powder compaction data, such effects have not been systematically evaluated in the literature. This work is aimed at quantitatively evaluating effects of inaccurate true density on tableting data analysis using the Ryshkewitch equation, sigma = sigma0 e - bepsilon, ...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1002/jps.20421

    authors： Sun CC

    更新日期：2005-09-01 00:00:00

  • Stereoselective pharmacokinetics and inversion of suprofen enantiomers in humans.

    abstract：:The stereoselective pharmacokinetics of suprofen enantiomers has been studied in humans by means of stable isotope-labeled pseudoracemate-diastereomer methodology. After a single oral dose of a near equimolar mixture of unlabeled-(R)-(-)- and [2H3]-(S)-(+)-suprofen [or unlabeled-(S)- and [2H3]-(R)-suprofen] to three h...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1002/jps.2600801116

    authors： Shinohara Y,Magara H,Baba S

    更新日期：1991-11-01 00:00:00

  • Effects of Product Handling Parameters on Particle Levels in a Commercial Factor VIII Product: Impacts and Mitigation.

    abstract：:To reduce the risk of immunogenicity that may be caused by therapeutic protein products, it is important to properly characterize subvisible particles and to develop strategies to reduce the levels of particles delivered to patients. In the present study, by using state-of-the-art methods to quantify particle levels, ...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1016/j.xphs.2018.08.022

    authors： Ueda T,Nakamura K,Abe Y,Carpenter JF

    更新日期：2019-01-01 00:00:00

  • Expression of human polyspecific renal organic cation transport activity in Xenopus laevis oocytes.

    abstract：:Polyspecific organic cation transporters in the basolateral and brush border membrane of the kidney play a role in the elimination of many clinically important drugs and endogenous compounds. In this study we report the functional expression of organic cation transport activity in Xenopus laevis oocytes injected with ...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1021/js960509l

    authors： Chun JK,Piquette-Miller M,Zhang L,Giacomini KM

    更新日期：1997-06-01 00:00:00

  • Ocular pharmacokinetics of a novel tetrahydroquinoline analog in rabbit: absorption, disposition, and non-compartmental analysis.

    abstract：:The pharmacologically active compound (33% reduction in rabbit intraocular pressure recovery rate assay) 1-ethyl-6-fluoro-1,2,3,4-tetrahydroquinoline (MC4), which showed ocular hypotensive action and had optimum physicochemical properties, was characterized for its ocular absorption and distribution properties to bett...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1002/jps.22720

    authors： Pamulapati CR,Schoenwald RD

    更新日期：2011-12-01 00:00:00

  • Synthesis and irreversible beta-adrenergic blockade with a bromoacetamido derivative of betaxolol.

    abstract：:1-[4-(2-Cyclopropylmethoxyethyl)phenoxy]-3-[1-p-(bromoacetamidophe nyl) -2-methyl-2-propylamine]-2-propranol (8), which is a derivative of the beta 1-adrenergic agent betaxolol, was synthesized. Compound 8 showed less potent beta-adrenergic blocking activity than betaxolol in an in vitro test with guinea pig tracheal ...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1002/jps.2600741024

    authors： Amlaiky N,Leclerc G

    更新日期：1985-10-01 00:00:00

  • Explication of Definitional Description and Empirical Use of Fraction of Orally Administered Drugs Absorbed From the Intestine (Fa) and Intestinal Availability (Fg): Effect of P-glycoprotein and CYP3A on Fa and Fg.

    abstract：:Conventionally, it is believed that the fraction of orally administered drugs absorbed from the intestine (Fa) and intestinal availability (Fg) are independently determined by the apical membrane permeation and intestinal metabolism, respectively. However, the validity of this belief has not been well discussed, and F...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.xphs.2015.11.005

    authors： Tanaka Y,Kitamura Y,Maeda K,Sugiyama Y

    更新日期：2016-02-01 00:00:00

  • Molecular modeling of beta-cyclodextrin complexes with nootropic drugs.

    abstract：:The geometry and structural features of the inclusion complexes of beta-cyclodextrin (beta-CD) with the chiral antiamnesic drugs (+/-)-1-benzyl-4-hydroxymethylpyrrolidin-2-one (WEB-1868). (+/-)-1-benzenesulfonyl-5-ethoxypyrrolidin-2-one (RU-35929), and (+/-)-1-(3-pyridinlysulfonyl)-5-ethoxypyrrolidin-2-one (RU-47010) ...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1002/jps.2600811205

    authors： Amato ME,Djedaïni F,Pappalardo GC,Perly B,Scarlata G

    更新日期：1992-12-01 00:00:00

  • Effect of temperature on binding of warfarin by human serum albumin.

    abstract：:The in vitro binding of warfarin by human serum albumin was studied at various temperatures and at pH 7.4 by a frontal gel filtration technique. The results can be best described in terms of a two class-of-binding site model, in which the numbers of primary and secondary sites are constrained to the average values for...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1002/jps.2600651127

    authors： Oester YT,Keresztes-Nagy S,Mais RF,Becktel J,Zaroslinski JF

    更新日期：1976-11-01 00:00:00

  • Bioavailability assessment under quasi- and nonsteady-state conditions III: Application.

    abstract：:The applicability of bioavailability assessment at quasi- and nonsteady state is illustrated with data from a study comparing two formulations of amitriptyline hydrochloride in humans. Relative bioavailability as a function of the observed mean plasma concentrations may be expressed in closed form, provided the affect...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1002/jps.2600651124

    authors： Bondi JV,Hucker HB,Yeh KC,Kwan KC

    更新日期：1976-11-01 00:00:00

  • In vitro adsorption studies of cimetidine.

    abstract：:The adsorption of cimetidine on selected pharmaceuticals including kaolin, activated charcoal, talc, and nonsystemic antacids was determined at pH 5.0 and 25 degrees. The Langmuir and Freundlich adsorption isotherms showed that cimetidine adsorption was significant with activated charcoal, kaolin, talc, and magnesium ...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1002/jps.2600690329

    authors： Ganjian F,Cutie AJ,Jochsberger T

    更新日期：1980-03-01 00:00:00

  • Enabling tablet product development of 5-fluorocytosine through integrated crystal and particle engineering.

    abstract：:The antifungal drug, 5-fluorocytosine (FC), is marketed as a capsule (250 or 500 mg strength) instead of the preferred tablet dosage form. Through systematic characterization of solid-state properties, including mechanical properties, we identify tabletability and poor physical stability of FC as the problems that lik...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1002/jps.23876

    authors： Perumalla SR,Sun CC

    更新日期：2014-04-01 00:00:00

  • My mentors.

    abstract：:This paper traces the academic genealogy of Professor Takeru Higuchi, who is considered "The Father of Physical Pharmacy" because of his contributions to the science of drug formulation and delivery and his impact in mentoring a whole generation of post-World War II pharmaceutical scientists. As one who was mentored b...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 传,社论,历史文章

    doi：10.1002/jps.1049

    authors： Stella VJ

    更新日期：2001-08-01 00:00:00

  • In Vitro and In Vivo Studies of Polyvinyl Pyrrolidone-Coated Sparfloxacin-Loaded Ring Contact Lens to Treat Conjunctivitis.

    abstract：:Currently, conjunctivitis is treated by frequent high dose administration of sparfloxacin eye drop solution. However, the eye drops are inconvenient because of low bioavailability, short ocular drug residence time, and need of frequent instillation, which lead to patient noncompliance affecting the routine life style ...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1016/j.xphs.2020.02.008

    authors： Ran W,Ma H,Li M

    更新日期：2020-06-01 00:00:00

  • A Formulation Development Approach to Identify and Select Stable Ultra-High-Concentration Monoclonal Antibody Formulations With Reduced Viscosities.

    abstract：:High protein concentration formulations are required for low-volume administration of therapeutic antibodies targeted for subcutaneous, self-administration by patients. Ultra-high concentrations (≥150 mg/mL) can lead to dramatically increased solution viscosities, which in turn can lead to stability, manufacturing, an...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1016/j.xphs.2017.06.017

    authors： Whitaker N,Xiong J,Pace SE,Kumar V,Middaugh CR,Joshi SB,Volkin DB

    更新日期：2017-11-01 00:00:00

  • Nasal drug administration: potential for targeted central nervous system delivery.

    abstract：:Nasal administration as a means of delivering therapeutic agents preferentially to the brain has gained significant recent interest. While some substrates appear to be delivered directly to the brain via this route, the mechanisms governing overall brain uptake and exposure remain unclear. Some substrates utilize the ...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章,评审

    doi：10.1002/jps.20318

    authors： Graff CL,Pollack GM

    更新日期：2005-06-01 00:00:00

  • Imaging pharmaceutical tablets with optical coherence tomography.

    abstract：:Optical coherence tomography (OCT) is a recently developed optical technique that produces depth profiles of three-dimensional objects. It is a nondestructive interferometric method responding to refractive index variation in the sample under study and can reach a penetration depth of a few millimetres. OCT employs ne...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1002/jps.21844

    authors： Mauritz JM,Morrisby RS,Hutton RS,Legge CH,Kaminski CF

    更新日期：2010-01-01 00:00:00

  • Isolation and characterization of the sesquiterpene lactones costunolide, parthenolide, costunolide diepoxide, santamarine, and reynosin from Magnolia grandiflora L.

    abstract：:The germacranolide sesquiterpene lactones costunolide, parthenolide, and costunolide diepoxide were isolated from the leaves of Magnolia grandiflora L. Costunolide diepoxide might be, at least in part, an artifact derived from air oxidation of parthenolide. The root bark yielded only costunolide together with the two ...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1002/jps.2600670319

    authors： el-Feraly FS,Chan YM

    更新日期：1978-03-01 00:00:00

  • Intravenous dosing conditions may affect systemic clearance for highly lipophilic drugs: implications for lymphatic transport and absolute bioavailability studies.

    abstract：:The clearance (Cl) and volume of distribution (V(ss)) of a lipophilic, lymphatically transported drug, halofantrine (Hf) have been evaluated after intravenous delivery to the systemic circulation in ex vivo lymph and plasma, and compared with the data obtained after administration of a lipid-based emulsion and a lipid...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1002/jps.23211

    authors： Caliph SM,Trevaskis NL,Charman WN,Porter CJ

    更新日期：2012-09-01 00:00:00

  • Stabilizing effect of fructose on aqueous solutions of hydrocortisone.

    abstract：:Accelerated stability studies (37 degrees, 47 degrees, and 57 degrees) were conducted on buffered aqueous solutions (pH 7.4, 8.4, and 9.4) of hydrocortisone in the presence of various molar ratios of D-fructose. First-order degradation was observed. Significant improvement in hydrocortisone stability was seen in those...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1002/jps.2600720930

    authors： Bansal NP,Holleran EM,Jarowski CI

    更新日期：1983-09-01 00:00:00

  • Effect of certain drugs in perfused human placenta XII: autacoid antagonism by phenothiazines.

    abstract：:The effects of chlorpromazine, prochlorperazine, and trifluoperazine on the pressor actions of serotonin, angiotensin, and bradykinin in the perfused vessels of full-term human placentas were investigated. A significant inhibition of the effect of serotonin was observed with trifluoperazine and chlorpromazine but not ...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1002/jps.2600651020

    authors： Wolstenholme WW,Gautieri RF

    更新日期：1976-10-01 00:00:00

  • Cardiovascular effects of two potential beta-hydroxylase inhibitors.

    abstract：:The purpose of this study was to evaluate the cardiovascular effects of two potential beta-hydroxylase inhibitors, a dithiocarbamate and a thiourea derivative of d-amphetamine, 1 and 2, respectively. These compounds when given intravenously elicited a significant dose-dependent depressor effect in normotensive rats an...

    journal_title：Journal of pharmaceutical sciences

    pub_type： 杂志文章

    doi：10.1002/jps.2600740621

    authors： Venugopalan CS,Jenkins HJ

    更新日期：1985-06-01 00:00:00