Abstract:
:The germacranolide sesquiterpene lactones costunolide, parthenolide, and costunolide diepoxide were isolated from the leaves of Magnolia grandiflora L. Costunolide diepoxide might be, at least in part, an artifact derived from air oxidation of parthenolide. The root bark yielded only costunolide together with the two eudesmanolides, santamarine and reynosin. In an attempt to synthesize costunolide diepoxide, the action of m-chloroperbenzoic acid on parthenolide and on costunolide was studied. The products were costunolide diepoxide from parthenolide and the two cyclized derivatives, santamarine and reynosin, from costunolide. The elusive 1,10-epoxide was obtained by epoxidizing costunolide using a biphasic system containing sodium bicarbonate. Under these conditions, epoxidation of costunolide took place without cyclization.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
el-Feraly FS,Chan YMdoi
10.1002/jps.2600670319subject
Has Abstractpub_date
1978-03-01 00:00:00pages
347-50issue
3eissn
0022-3549issn
1520-6017pii
S0022-3549(15)39893-2journal_volume
67pub_type
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