Abstract:
:Oxidative-reductive interconversion of the methylthiomethyl ester of aspirin and the corresponding sulfoxide and sulfone derivatives can be detected in rat liver homogenate, in addition to the extremely facile hydrolysis of these esters. The methylthiomethyl and methylsulfinylmethyl 2-acetoxybenzoates penetrate freshly excised hairless mice skin rather easily with the simultaneous hydrolysis of the two ester functions. Contrary to in vivo observations in dogs, where significant amounts of aspirin formed, the prodrugs cleave to salicylic acid and/or salicylate esters rather than aspirin.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Loftsson T,Bodor Ndoi
10.1002/jps.2600700710subject
Has Abstractpub_date
1981-07-01 00:00:00pages
756-8issue
7eissn
0022-3549issn
1520-6017pii
S0022-3549(15)43781-5journal_volume
70pub_type
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