Abstract:
:Benzydamine hydrochloride (Tantum, 1) is a photoallergic and phototoxic anti-inflammatory and analgesic agent. This drug is photolabile under aerobic and anaerobic conditions. Irradiation of a methanol solution of benzydamine under oxygen or argon at 300 nm affords 5-hydroxybenzydamine (2) and 2-beta-dimethylaminopropyl-1-benzylindalolin-3-one (3) as the main isolated and spectroscopically identified photoproducts. A radical intermediate was evidenced by thiobarbituric acid that was used as a radical sonde, as well as by the dimerization of cysteine. Erythrocyte lysis photosensitized by 1, 2, and 3 was investigated.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Vargas F,Rivas C,Machado R,Sarabia Zdoi
10.1002/jps.2600820407subject
Has Abstractpub_date
1993-04-01 00:00:00pages
371-2issue
4eissn
0022-3549issn
1520-6017pii
S0022-3549(15)49099-9journal_volume
82pub_type
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