Abstract:
:Judicious choice of the salt form of a drug can greatly affect the aqueous solubility and formulation of the compound. The objective of this work was to demonstrate the effect of various counteranions on the aqueous solubility of the antimalarial agent alpha-(2-piperidyl)-3, 6-bis(trifluoromethyl)-9-phenanthrenemethanol. Several organic salts of this drug were studied. The methods of synthesis, the apparent aqueous solubilities, and in vitro dissolution tests for these salts are reported. The lactate salt was 200 times as soluble as the hydrochloride salt. This enhanced solubility suggests that parenteral administration of this drug may now be feasible.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Agharkar S,Lindenbaum S,Higuchi Tdoi
10.1002/jps.2600650533subject
Has Abstractpub_date
1976-05-01 00:00:00pages
747-9issue
5eissn
0022-3549issn
1520-6017pii
S0022-3549(15)40750-6journal_volume
65pub_type
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