Increasing process understanding by analyzing complex interactions in experimental data.


:There is a recognized need for new approaches to understand unit operations with pharmaceutical relevance. A method for analyzing complex interactions in experimental data is introduced. Higher-order interactions do exist between process parameters, which complicate the interpretation of experimental results. In this study, experiments based on mixed factorial design of coating process were performed. Drug release was analyzed by traditional analysis of variance (ANOVA) and generalized multiplicative ANOVA (GEMANOVA). GEMANOVA modeling is introduced in this study as a new tool for increased understanding of a coating process. It was possible to model the response, that is, the amount of drug released, using both mentioned techniques. However, the ANOVA model was difficult to interpret as several interactions between process parameters existed. In contrast to ANOVA, GEMANOVA is especially suited for modeling complex interactions and making easily understandable models of these. GEMANOVA modeling allowed a simple visualization of the entire experimental space. Furthermore, information was obtained on how relative changes in the settings of process parameters influence the film quality and thereby drug release.


J Pharm Sci


Naelapää K,Allesø M,Kristensen HG,Bro R,Rantanen J,Bertelsen P




Has Abstract


2009-05-01 00:00:00














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    journal_title:Journal of pharmaceutical sciences

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    abstract::(+-)-Carbovir [(+-)-9-[4 alpha-(hydroxymethyl)-cyclopent-2-ene-1 alpha-yl]guanine; NSC 614846] is a novel carbocyclic nucleoside analogue which has been shown to be a potent and selective inhibitor of HIV in vitro. As part of an effort to develop a parenteral formulation for subsequent clinical and toxicological evalu...

    journal_title:Journal of pharmaceutical sciences

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    authors: Anderson BD,Chiang CY

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    abstract::Exposure of 4-methoxy-2-(3-phenyl-2-propynyl)phenol (CO/1828) to air and light (accelerated by temperature) yields 1-(2-hydroxy-5- methoxyphenyl)-3-phenylpropynone as the major degradation product. With extraction, this product rapidly degrades to 5-methoxyaurone and 6-methoxyflavone. In addition, a mixture of dimeric...

    journal_title:Journal of pharmaceutical sciences

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    authors: Schiavi M,Serafini S,Italia A,Villa M,Fronza G,Selva A

    更新日期:1992-08-01 00:00:00

  • Usefulness of a novel Caco-2 cell perfusion system. I. In vitro prediction of the absorption potential of passively diffused compounds.

    abstract::A simple, reliable, and user friendly system was established to cultivate Caco-2 cell monolayer for epithelial transport studies. After an initial growth period of 1 week in a CO(2) incubator, Caco-2 cells were cultivated in an automated continuous perfusion system (Minucells and Minutissue, Germany). Medium was const...

    journal_title:Journal of pharmaceutical sciences

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    authors: Masungi C,Borremans C,Willems B,Mensch J,Van Dijck A,Augustijns P,Brewster ME,Noppe M

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  • A theoretical analysis of a new drug delivery system: a cylindrical device with a vertical opening on its surface.

    abstract::A theoretical analysis of a proposed drug delivery device is presented. The device is of cylindrical shape with an opening on its side surface. Analytical expressions for the temporal variations in the amount of drug released and the size of the unreleased portion of the device are derived. The result of numerical sim...

    journal_title:Journal of pharmaceutical sciences

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    authors: Hsu JP,Ting C,Lin MJ

    更新日期:1992-09-01 00:00:00

  • Facile synthesis of glycol metabolites of phenethylamine drugs.

    abstract::High yields of potential glycol metabolites of p-synephrine, epinephrine, octopamine, and normacromerine can be obtained from the readily available monosubstituted and disubstituted acetophenones. The general procedure involves alpha-bromination followed by displacement with acetate ion and reduction with lithium alum...

    journal_title:Journal of pharmaceutical sciences

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    authors: Holshouser MH,Kolb M

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  • Dissolution studies of drug formulations using ion-selective electrodes as sensors in an air-segmented continuous flow analyzer.

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    authors: Mitsana-Papazoglou A,Christopoulos TK,Diamandis EP,Koupparis MA

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    journal_title:Journal of pharmaceutical sciences

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    authors: Solymoss B,Krajny M,Varga S

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    authors: Kim HL,McAuley A,McGuire J

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    authors: Veng-Pedersen P,Modi NB

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    pub_type: 杂志文章


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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Terahara T,Mitragotri S,Langer R

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Korsmeyer RW,Gurny R,Doelker E,Buri P,Peppas NA

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Sanvordeker DR,Chien YW,Lin TK,Lambert HJ

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Musteata FM,Pawliszyn J,Qian MG,Wu JT,Miwa GT

    更新日期:2006-08-01 00:00:00

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Qiu Z,Stowell JG,Cao W,Morris KR,Byrn SR,Carvajal MT

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    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


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