Abstract:
:A novel approach using a self-setting hydroxyapatite (HAP) cement as a skeletal drug-delivery system has been proposed to solve the problem of delivering drugs to skeletal tissue at sufficiently high local concentrations for desirable therapeutic effects. HAP cements loaded with antibiotics can be formed in situ and can be used as bonding materials between bone and prostheses, as well as drug-release devices. The cement also possesses sufficient mechanical strength to be a potential bone grafting material. Using cephalexin and norfloxacin as model drugs, we observed continuous in vitro release profiles of these compounds from cement pellets loaded 0.9-4.8% by weight with one of the drugs. This drug-release pattern correlated well with the Higuchi model. This hydroxyapatite cement drug-delivery system can be applied in the treatment of osteomyelitis and infected compound fractures.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Yu D,Wong J,Matsuda Y,Fox JL,Higuchi WI,Otsuka Mdoi
10.1002/jps.2600810611subject
Has Abstractpub_date
1992-06-01 00:00:00pages
529-31issue
6eissn
0022-3549issn
1520-6017pii
S0022-3549(15)48868-9journal_volume
81pub_type
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journal_title:Journal of pharmaceutical sciences
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