Abstract：
:The aim was to study a new method of dissolution in vitro, the "Bio-Dis" apparatus, and to compare it with the classical rotating bottle method. Several theophylline controlled-release drug dosage forms were studied. Dissolution testing was performed in increasing pH in standard conditions and after treatment with peanut oil in order to simulate high fat meals and to correlate the in vitro percent dissolved with the in vivo results obtained. The in vivo study was carried out on three groups of healthy volunteers receiving each dosage form in a randomized order just before a high fat breakfast or in the fasting state. The in vitro percent dissolved obtained was compared with those published results obtained with rotating bottles. A linear relationship was established between these results. From the in vivo absorbed percentages calculated according to the Wagner-Nelson method, a linear relation was found between the in vivo percent absorbed and the in vitro percent dissolved in the different conditions. The relationships observed are similar for all the forms under both conditions. The "Bio-Dis" offers advantages over the rotating bottle method. The study reported allows this dissolution apparatus to be proposed as an alternative to the rotating bottle apparatus.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Esbelin B,Beyssac E,Aiache JM,Shiu GK,Skelly JPdoi
10.1002/jps.2600801017subject
Has Abstractpub_date
1991-10-01 00:00:00pages
991-4issue
10eissn
0022-3549issn
1520-6017pii
S0022-3549(15)48656-3journal_volume
80pub_type
临床试验,杂志文章,随机对照试验abstract：:The morphology of spray-dried particles composed of psicose and hydroxypropyl methylcellulose was modified by adding ammonium bicarbonate (ABC) to the solution. The surface structure of the particles was altered by immediate transformation of ABC to gaseous components during the spray drying. As a result, low-density ...
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doi：10.1002/jps.2600650629
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更新日期：2006-02-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
pub_type： 杂志文章
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abstract：:A study of the pH of saliva produced by humans sucking hard candy lozenges containing zinc gluconate and citric acid demonstrated the probability that the formulation delivered an insignificant amount of the contained zinc as Zn2+. This could account for the negative results of several clinical studies of this lozenge...
journal_title：Journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.1002/jps.2600810205
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journal_title：Journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.1002/jps.20667
更新日期：2006-08-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章,随机对照试验
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journal_title：Journal of pharmaceutical sciences
pub_type： 杂志文章
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更新日期：1994-04-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
pub_type： 杂志文章
doi：10.1002/jps.2600830306
更新日期：1994-03-01 00:00:00
abstract：:In many manufacturing and research areas, the ability to accurately monitor and characterize nanoparticles is becoming increasingly important. Nanoparticle tracking analysis is rapidly becoming a standard method for this characterization, yet several key factors in data acquisition and analysis may affect results. Nan...
journal_title：Journal of pharmaceutical sciences
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doi：10.1016/j.xphs.2016.02.005
更新日期：2016-04-01 00:00:00
