Abstract:
:A new extraction-spectrophotometric method for the determination of hydralazine, based on its reaction with 2-hydroxy-1-naphthaldehyde at 25 degrees C, is described. The calibration curve was linear between 0.4 and 6 mg/mL of hydralazine. The molar absorbtivity of the product at 408 nm is 40,900 L.mol-1.cm-1. The method described was applied to the analysis of hydralazine in pharmaceutical preparations containing reserpine, hydrochlorothiazide, bendrofluorthiazine, propranolol, and other substances. The agreement with the U.S.P. XXI method was satisfactory for tablets and injections, but not for pellets.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Mari-Buigues J,Mañes-Vinuesa J,Garcia-Domenech R,Pous-Miralles Gdoi
10.1002/jps.2600800716subject
Has Abstractpub_date
1991-07-01 00:00:00pages
690-2issue
7eissn
0022-3549issn
1520-6017pii
S0022-3549(15)48583-1journal_volume
80pub_type
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