Abstract:
:Knowledge of slip or cleavage planes can facilitate the fundamental understanding of mechanical properties of organic crystals important to pharmaceutical operations, such as tableting and milling. Slip/cleavage planes were frequently assigned based on attachment energy calculation. These crystallographic planes can also be identified by visualization of crystals characterized by stacking layers of high molecular density and often strengthened by two-dimensional hydrogen bonding network. Using 14 organic crystals exhibiting such layered structures, predicted slip planes by attachment energy calculation employing three force fields, Dreiding, cvff, and COMPASS, were compared to those identified by crystal structure visualization. Overall, slip/cleavage planes in <50% crystals were successfully predicted by attachment energy calculation. Thus predicted slip/cleavage planes by attachment energy calculation may not be always accurate and should be treated with caution.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Sun CC,Kiang YHdoi
10.1002/jps.21234subject
Has Abstractpub_date
2008-08-01 00:00:00pages
3456-61issue
8eissn
0022-3549issn
1520-6017pii
S0022-3549(16)32642-9journal_volume
97pub_type
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