Abstract:
:A rapid, sensitive, and accurate reversed-phase HPLC method has been developed for the analysis and quantification of pharmaceutical formulations containing tyrothricin (1), an antibiotic used in antiseptic buccal compressed tablets for local application. The assay has been carried out under isocratic conditions, using a stationary phase of alumina particles coated with polybutadiene and an alkaline mobile phase (pH = 8.2). No HPLC method was reported for the analysis of 1. So, this new technique is an alternative to the slow and tedious microbiological methods. On the other hand, it allows the simultaneous quantification of 1, benzocaine (2), and menthol (3), an aromatic compound not currently analyzed by liquid chromatography.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Caraballo I,Fernandez-Arevalo M,Holgado MA,Vela MT,Rabasco AMdoi
10.1002/jps.2600830815subject
Has Abstractpub_date
1994-08-01 00:00:00pages
1147-9issue
8eissn
0022-3549issn
1520-6017pii
S0022-3549(15)49556-5journal_volume
83pub_type
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