Abstract:
:Crystallization of drugs in metastable, supersaturated adhesive polymeric matrices in transdermal drug delivery devices can be avoided by determination of the solubility of the drug in the adhesive polymer. A novel method is described to determine the solubility of the drug in polymeric matrices. Unlike existing methods, this method does not require a long and uncertain experimental time, and is accurate. In this study, an easy and accurate method is presented for the determination of solubility of drugs in polymers based on the relationship between thermodynamic activity of drugs and steady-state flux. In particular, the steady-state flux from a reference saturated solution across a test membrane was compared to an experimentally determined relationship between the polymeric loading concentration and the observed steady-state fluxes. The validity of this method was demonstrated by comparing the results to microscopic observation of crystallization and the study of aged drug-loaded adhesives for lidocaine as a model drug and an acrylate pressure-sensitive adhesive as a model polymer. The solubility of lidocaine was 20.8 +/- 0.5% (w/w) in the acrylate polymer.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Jasti BR,Berner B,Zhou SL,Li Xdoi
10.1002/jps.20122subject
Has Abstractpub_date
2004-08-01 00:00:00pages
2135-41issue
8eissn
0022-3549issn
1520-6017pii
S0022-3549(16)31561-1journal_volume
93pub_type
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