Abstract:
:We extend and modify the Noyes-Whitney equation and the Hixon-Crowell cube root law to include surface roughness effects on the dissolution rate of drugs. The problem is treated theoretically in terms of the fractal reaction dimension, DR, of the effective surface which undergoes dissolution. Effects of changes in DR on the dissolution rate are identified and explained.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Farin D,Avnir Ddoi
10.1002/jps.2600810111subject
Has Abstractpub_date
1992-01-01 00:00:00pages
54-7issue
1eissn
0022-3549issn
1520-6017pii
S0022-3549(15)48741-6journal_volume
81pub_type
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