Use of fractal geometry to determine effects of surface morphology on drug dissolution.

Abstract:

:We extend and modify the Noyes-Whitney equation and the Hixon-Crowell cube root law to include surface roughness effects on the dissolution rate of drugs. The problem is treated theoretically in terms of the fractal reaction dimension, DR, of the effective surface which undergoes dissolution. Effects of changes in DR on the dissolution rate are identified and explained.

journal_name

J Pharm Sci

authors

Farin D,Avnir D

doi

10.1002/jps.2600810111

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

54-7

issue

1

eissn

0022-3549

issn

1520-6017

pii

S0022-3549(15)48741-6

journal_volume

81

pub_type

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