Use of fractal geometry to determine effects of surface morphology on drug dissolution.


:We extend and modify the Noyes-Whitney equation and the Hixon-Crowell cube root law to include surface roughness effects on the dissolution rate of drugs. The problem is treated theoretically in terms of the fractal reaction dimension, DR, of the effective surface which undergoes dissolution. Effects of changes in DR on the dissolution rate are identified and explained.


J Pharm Sci


Farin D,Avnir D




Has Abstract


1992-01-01 00:00:00














  • VLDL-resembling phospholipid-submicron emulsion for cholesterol-based drug targeting.

    abstract::The objective of the current study was to develop and evaluate VLDL-resembling phospholipid-submicron emulsion (PSME) as a carrier system for new cholesterol-based compounds for targeted delivery to cancer cells. BCH, a boronated cholesterol compound, was originally developed in our laboratory to mimic the cholesterol...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Shawer M,Greenspan P,ØIe S,Lu DR

    更新日期:2002-06-01 00:00:00

  • Application of central composite designs to the preparation of polycaprolactone nanoparticles by solvent displacement.

    abstract::Cyclosporin A (CyA) is a good candidate for incorporation in colloidal carriers such as nanoparticles (NP) that would diminish the adverse effects associated with its use under conventional pharmaceutical dosage forms and improve bioavailability after oral administration. In this study a composite rotational experimen...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Molpeceres J,Guzman M,Aberturas MR,Chacon M,Berges L

    更新日期:1996-02-01 00:00:00

  • Effect of diphenhydramine on methaqualone metabolism: an in vitro study.

    abstract::A GLC assay to quantitate the methaqualone metabolite 2-methyl-3-(2-hydroxymethylphenyl)-4(3H)-quinazolinone was developed. Standard curves were linear, and recovery of the metabolite from tissue homogenates averaged 89%. In vitro metabolism of methaqualone by the 10,000Xg supernatant fraction of rat liver homogenate ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Hindmarsh KW,Hamon NW,LeGatt DF,Wallace SM

    更新日期:1978-11-01 00:00:00

  • Estimating the relative stability of polymorphs and hydrates from heats of solution and solubility data.

    abstract::The transition temperature, T(t), of polymorphs is estimated from both their heats of solution and solubilities (or intrinsic dissolution rates) determined at any one temperature (e.g., ambient). At a given temperature, T, the enthalpy difference, DeltaH, between polymorphs, I and II, is equal to the difference betwee...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Gu CH,Grant DJ

    更新日期:2001-09-01 00:00:00

  • The complex inter-relationships between protein flexibility and stability.

    abstract::The ability to successfully formulate and manufacture therapeutic protein dosage forms requires a thorough understanding of their physico-chemical properties. Proteins are inherently dynamic molecules of marginal stability. These properties present unique challenges to the pharmaceutical scientist attempting to develo...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章,评审


    authors: Kamerzell TJ,Middaugh CR

    更新日期:2008-09-01 00:00:00

  • Inhibitory effect of valsartan on the intestinal absorption and renal excretion of bestatin in rats.

    abstract::Peptidomimetic drugs have favorable bioavailability owing to H(+)/peptide transporter 1 (PEPT1) located in the intestine. Sartans are commonly used and likely coadministered with peptidomimetic drugs in the clinic; however, in vivo interactions between sartans and peptidomimetic drugs have not been systemically unders...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Huo X,Liu Q,Wang C,Meng Q,Sun H,Peng J,Ma X,Sun P,Liu K

    更新日期:2014-02-01 00:00:00

  • Drug delivery trends in clinical trials and translational medicine: evaluation of pharmacokinetic properties in special populations.

    abstract::In spite of the recent advances in technology to optimize the absorption, distribution, metabolism and elimination (ADME) properties of new and promising medicinal products to reduce clinical failures, the investigation of drug disposition in the pediatric and elderly populations continues to be under evaluated. With ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章,评审


    authors: Chien JY,Ho RJ

    更新日期:2011-01-01 00:00:00

  • Application of the ammonia gas-sensing electrode: determination of drugs having a carbothionamido group by decomposition with acid.

    abstract::A method to determine drugs having a carbothionamido group using an ammonia gas-sensing electrode is described. To obtain analytical accuracy, the effect of factors that influence the potential is also discussed. Ethionamide or prothionamide was refluxed with 20% HCl to give ammonium chloride, hydrogen sulfide, and a ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Tagami S,Maeda H

    更新日期:1983-09-01 00:00:00

  • Physicochemical properties of A-75998, an antagonist of luteinizing hormone releasing hormone.

    abstract::The physicochemical properties of A-75998, a synthetic antagonist of luteinizing hormone releasing hormone with potential for treatment of hormone-sensitive cancers and endometriosis, are described. An accelerated solution stability study indicated that the compound is relatively stable and showed a U-shaped pH-rate p...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Cannon JB,Krill SL,Porter WR

    更新日期:1995-08-01 00:00:00

  • Ketoconazole Stereoisomers Differentially Induce Cytochrome P450 1A1 Between Human Hepatoma HepG2 and Mouse Hepatoma Hepa1c1c7 Cells.

    abstract::Ketoconazole (KTZ) has 2 chiral centers with the therapeutically active form being a racemic mixture of 2 cis-enantiomers, namely, (2R,4S)-(+)-KTZ and (2S,4R)-(-)-KTZ. The aims of the present study were to examine the effects of (+)-KTZ, (-)-KTZ, and (±)-KTZ on aryl hydrocarbon receptor activation and subsequently CYP...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Anwar-Mohamed A,El-Sherbeni AA,Hamdy DA,Korashy HM,Brocks DR,El-Kadi AO

    更新日期:2016-03-01 00:00:00

  • Inactivation of gamma-glutamylcysteine synthetase by SAPH-3 disulfide: role of the histaminyl moiety.

    abstract::Certain disulfide analogues of cystamine were prepared and evaluated for the ability to inhibit gamma-glutamylcysteine synthetase (GCS), the rate-limiting enzyme in glutathione synthesis. The compound SAPH-3 disulfide (2a) was found to be the most effective inactivator of GCS reported to date. Studies of structural an...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Schor NF,Cheng B,Siuda JF

    更新日期:1991-04-01 00:00:00

  • Anisotropic surface chemistry of aspirin crystals.

    abstract::The wettability of the (001), (100), and (011) crystallographic facets of macroscopic aspirin crystals has been experimentally investigated using a sessile drop contact angle (theta) method. theta for a nonpolar liquid was very similar for all three facets, though significant theta differences were observed for three ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Heng JY,Bismarck A,Lee AF,Wilson K,Williams DR

    更新日期:2007-08-01 00:00:00

  • Variations in compaction behaviour for tablets of different size and shape, revealed by small-angle X-ray scattering.

    abstract::Local variations in compaction behaviour were investigated, for specimens of different shapes and thickness, comparing predictions from finite element (FE) modelling and results from a recently developed method using small-angle X-ray scattering (SAXS). Good agreement was generally obtained between these methods, in t...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Laity PR,Han L,Elliott J,Cameron RE

    更新日期:2010-10-01 00:00:00

  • Comparison of the pharmacokinetics of dolasetron and its major active metabolite, reduced dolasetron, in dog.

    abstract::Dolasetron mesilate (Anzemet) ((2 alpha, 6 alpha, 8 alpha, 9a beta)-octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl-1 H-indole-3-carboxylate monomethane-sulfonate) is a 5-HT3 receptor antagonist, which is in development for the treatment of chemotherapy-induced emesis. The ketone moiety of dolasetron is rapidly reduced...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Dow J,Francesco GF,Berg C

    更新日期:1996-07-01 00:00:00

  • Effect of certain drugs in perfused human placenta XII: autacoid antagonism by phenothiazines.

    abstract::The effects of chlorpromazine, prochlorperazine, and trifluoperazine on the pressor actions of serotonin, angiotensin, and bradykinin in the perfused vessels of full-term human placentas were investigated. A significant inhibition of the effect of serotonin was observed with trifluoperazine and chlorpromazine but not ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Wolstenholme WW,Gautieri RF

    更新日期:1976-10-01 00:00:00

  • Molecular modeling of beta-cyclodextrin complexes with nootropic drugs.

    abstract::The geometry and structural features of the inclusion complexes of beta-cyclodextrin (beta-CD) with the chiral antiamnesic drugs (+/-)-1-benzyl-4-hydroxymethylpyrrolidin-2-one (WEB-1868). (+/-)-1-benzenesulfonyl-5-ethoxypyrrolidin-2-one (RU-35929), and (+/-)-1-(3-pyridinlysulfonyl)-5-ethoxypyrrolidin-2-one (RU-47010) ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Amato ME,Djedaïni F,Pappalardo GC,Perly B,Scarlata G

    更新日期:1992-12-01 00:00:00

  • Preservative and Irritant Capacity of Biosurfactants From Different Sources: A Comparative Study.

    abstract::One of the most important challenges for pharmaceutical and cosmetic industries is solubilization and preservation of their active ingredients. Therefore, most of these formulations contain irritant chemical additives to improve their shelf-life and the solubility of hydrophobic ingredients. An interesting alternative...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Rodríguez-López L,Rincón-Fontán M,Vecino X,Cruz JM,Moldes AB

    更新日期:2019-07-01 00:00:00

  • Differentiation of subvisible silicone oil droplets from irregular standard dust particles.

    abstract::New methods are being applied to distinguish silicone oil droplets from subvisible particles in therapeutic protein formulations. The need to standardize these methods and compare them to established methods is critical to increase the understanding of the risks from protein aggregation and other subvisible particulat...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Vandesteeg N,Kilbert C

    更新日期:2013-06-01 00:00:00

  • Conformational color polymorphism and control of crystallization of 5-methyl-2-[(4-methyl-2-nitrophenyl)amino]-3-thiophenecarbonitrile.

    abstract::5-Methyl-2-[(4-methyl-2-nitrophenyl)amino]-3-thiophenecarbonitrile is an example of conformational and color polymorphism. The compound crystallizes in red (R), dark red (DR), light red (LR), and orange (O) modifications. There are two specific goals for this study. One is to characterize the complex thermodynamic rel...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: He X,Griesser UJ,Stowell JG,Borchardt TB,Byrn SR

    更新日期:2001-03-01 00:00:00

  • Slow motion picture of protein inactivation during single-droplet drying: a study of inactivation kinetics of L-glutamate dehydrogenase dried in an acoustic levitator.

    abstract::A novel technique is presented to allow measurement of the kinetics of protein inactivation during drying of an acoustically levitated single droplet. Droplets/particles are removed from the acoustic field after various times during drying, and the state of the protein within them is analyzed. The influence of drying ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Lorenzen E,Lee G

    更新日期:2012-06-01 00:00:00

  • Stereochemistries of geometric isomers of 4-(2-bromo-1,2-diphenylvinyl)phenol, 4-(2-bromo-1,2-diphenyylamine: corrections of the literature.

    abstract::The stereochemistries of geometric isomers of 4-(2-bromo-1,2-diphenylvinyl)phenol, 4-(2-bromo-1,2-diphenylvinyl)anisole, and 2-[p-(2-bromo-1,2-diphenylvinyl)phenoxy]triethylamine were determined by conversion of the phenolic analog to the ethers and subsequent comparison of physical properties with those of 2-[p-(2-ch...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Richardson A Jr,Benson HD,Hite G

    更新日期:1976-10-01 00:00:00

  • Microstructure of calcium stearate matrix pellets: a function of the drying process.

    abstract::Drying is a common pharmaceutical process, whose potential to modify the final drug and/or dosage form properties is often underestimated. In the present study, pellets consisting of the matrix former calcium stearate (CaSt) incorporating the active pharmaceutical ingredient ibuprofen were prepared via wet extrusion a...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Schrank S,Kann B,Windbergs M,Glasser BJ,Zimmer A,Khinast J,Roblegg E

    更新日期:2013-11-01 00:00:00

  • Extended least squares (ELS) for pharmacokinetic models.

    abstract::An important part of pharmacokinetic research is fitting models to observed data and estimating the parameters in the model. In general, parameter estimation in pharmacokinetics is a subset of the general problem of nonlinear regression or parameter estimation in nonlinear regression models. The same criteria, algorit...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Metzler CM

    更新日期:1987-07-01 00:00:00

  • Carrier-mediated transport systems for glucose in mucosal cells of the human oral cavity.

    abstract::The in vitro uptake study was performed using the isolated cells of human oral mucosa, buccal and the dorsum of the tongue, to investigate the mechanisms of glucose uptake. The uptake of D-glucose was much larger in cells of the dorsum of the tongue than in buccal cells and was inhibited more extensively by 2-deoxy-D-...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 临床试验,杂志文章


    authors: Oyama Y,Yamano H,Ohkuma A,Ogawara K,Higaki K,Kimura T

    更新日期:1999-08-01 00:00:00

  • Difference spectrophotometric determination of p-hydroxybenzoic acid in presence of its esters.

    abstract::A difference spectrophotometric analytical method was developed for the selective determination of p-hydroxybenzoic acid in the presence of its alkyl esters without prior separation. Based on the spectral shift to a shorter wavelength accompanyint carboxyl dissociation, the procedure measures as little as 2% of this a...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Fink DW,Fink HC,Tolan JW,Blodinger J

    更新日期:1978-06-01 00:00:00

  • Rapid GLC determination of fusaric acid in biological fluids.

    abstract::A simple, sensitive GLC assay was developed for fusaric acid, the active metabolite of bupicomide, to follow the disposition of this investigational antihypertensive agent in patients undergoing therapy. Fusaric acid is efficiently extracted from biological samples, derivatized by on-column methylation, and chromatogr...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Fung KK,Koda RT,Maronde RF,Cohen JL

    更新日期:1976-04-01 00:00:00

  • Analysis of tricyclic antidepressants in human plasma by GLC--chemical-ionization mass spectrometry with selected ion monitoring.

    abstract::A method is described for the analysis of amitriptyline, doxepin, imipramine, nortriptyline, desmethyldoxepin, desipramine, and protriptyline in human plasma utlizing GLC-chemical-ionization mass spectrometry with selected ion monitoring. The assay is highly specific and is quantitative to at least 1 ng/ml with a stan...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Jenkins RG,Friedel RO

    更新日期:1978-01-01 00:00:00

  • Presentation of HIV-1 Envelope Trimers on the Surface of Silica Nanoparticles.

    abstract::Inducing immune responses protecting from HIV infection or at least controlling replication poses a huge challenge to modern vaccinology. An increasingly discussed strategy to elicit a potent and broad neutralizing antibody response is the immobilization of HIV's trimeric envelope (Env) surface receptor on a nanoparti...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Thalhauser S,Peterhoff D,Wagner R,Breunig M

    更新日期:2020-01-01 00:00:00

  • Protein transduction domain-containing microemulsions as cutaneous delivery systems for an anticancer agent.

    abstract::In this study, we developed cationic microemulsions containing a protein transduction domain (penetratin) for optimizing paclitaxel localization within the skin. Microemulsions were prepared by mixing a surfactant blend (BRIJ:ethanol:propylene glycol 2:1:1, w/w/w) with monocaprylin (oil phase) at 1.3:1 ratio, and addi...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Pepe D,McCall M,Zheng H,Lopes LB

    更新日期:2013-05-01 00:00:00

  • Synthesis and therapeutic testing of mono- and dialkyl esters of pentetic (diethylenetriaminepentaacetic) acid for decorporation of polymeric plutonium.

    abstract::The synthesis, characterization, and therapeutic evaluation of a series of partially esterified derivatives of pentetic (diethylenetriaminepentaacetic) acid are reported. These compounds were prepared in an attempt to promote increased decorporation of insoluble colloidal forms of plutonium, which are removed by pente...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Guilmette RA,Parks JE,Lindenbaum A

    更新日期:1979-02-01 00:00:00