Abstract：
:Emerging 3D printing technologies offer an exciting opportunity to create customized 3D objects additively from a digital design file. 3D printing may be further leveraged for personalized medicine, clinical trial, and controlled release applications. A wide variety of 3D printing methods exists, and many studies focus on extrusion-based 3D printing techniques that closely resemble hot melt extrusion. In this paper, we explore different pharmaceutical-grade feedstock materials for creating tablet-like dosage forms using a binder jet 3D printing method. In this method, pharmaceutical-grade powders are repeatedly spread onto a build plate, followed by inkjet printing a liquid binder to selectively bind the powders in a predetermined pattern. The physical properties of the pharmaceutical-grade powders and binders have been characterized and a molding method has been developed to select appropriate powder and binder materials for subsequent printing experiments. There was a correlation between the breaking forces of the molded and printed samples, but no clear correlation was observed for disintegration time, which was primarily controlled by the higher porosity of the printed samples. The breaking force and disintegration properties of as-printed and post-processed samples containing indomethacin as an active pharmaceutical ingredient have been measured and compared with relevant literature data.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Chang SY,Li SW,Kowsari K,Shetty A,Sorrells L,Sen K,Nagapudi K,Chaudhuri B,Ma AWKdoi
10.1016/j.xphs.2020.06.027subject
Has Abstractpub_date
2020-10-01 00:00:00pages
3054-3063issue
10eissn
0022-3549issn
1520-6017pii
S0022-3549(20)30360-9journal_volume
109pub_type
杂志文章abstract：:Oil-frozen water-in-oil-in-water (W₁/O/W₂) double emulsions (DE) containing ethanol up to 40% (w/v) in the external aqueous W₂ phase exhibited external coalescence upon thawing of the oil phase, releasing up to 85% of the encapsulated protein of the internal aqueous phase. These emulsions were studied in vitro as pote...
journal_title：Journal of pharmaceutical sciences
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abstract：:Eight analogs of the fentanyl-type analgesics, in which the piperidine ring is restricted into a boat conformation, were evaluated for analgesic activity. All analogs were less active than fentanyl, but interesting conformational and structural relationships were observed. Results of the study are discussed. ...
journal_title：Journal of pharmaceutical sciences
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abstract：:After intravenous administration of MK-826, a new carbapenem antibiotic, the compound exhibited nonlinear pharmacokinetics in rats and monkeys. In both species, time-averaged plasma clearance (based on total concentrations) increased about 5-fold over the 10- to 180-mg/kg dose range. MK-826 was extensively plasma prot...
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journal_title：Journal of pharmaceutical sciences
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journal_title：Journal of pharmaceutical sciences
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doi：10.1002/jps.2600801005
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journal_title：Journal of pharmaceutical sciences
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更新日期：2001-03-01 00:00:00
abstract：:Inducing immune responses protecting from HIV infection or at least controlling replication poses a huge challenge to modern vaccinology. An increasingly discussed strategy to elicit a potent and broad neutralizing antibody response is the immobilization of HIV's trimeric envelope (Env) surface receptor on a nanoparti...
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journal_title：Journal of pharmaceutical sciences
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journal_title：Journal of pharmaceutical sciences
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更新日期：2012-10-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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doi：10.1002/jps.2600790818
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abstract：:Application of ultrasound enhances transdermal transport of drugs (sonophoresis). The enhancement may result from enhanced diffusion due to ultrasound-induced skin alteration and/or from forced convection. To understand the relative roles played by these two mechanisms in low-frequency sonophoresis (LFS, 20 kHz), a th...
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abstract：:The development of sustained-release lithium (Li) tablets, intended to release the active principle at a rate of 1.0 mM/h for 10 h, was undertaken. The parameters used for the control of the release were the glyceril palmite-stearate content, the carboxypolymethylene content, and the compression force. The experimenta...
journal_title：Journal of pharmaceutical sciences
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doi：10.1002/jps.2600691130
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journal_title：Journal of pharmaceutical sciences
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journal_title：Journal of pharmaceutical sciences
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journal_title：Journal of pharmaceutical sciences
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abstract：:Recent in vitro and in vivo studies have suggested transscleral iontophoresis as a means for non-invasive drug delivery to the eye. However, there remains a lack of information of the iontophoretic transport behavior of the sclera. The objective of the present study was to investigate the effects of permeant concentra...
journal_title：Journal of pharmaceutical sciences
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