Abstract:
:Evidence is provided for the existence of a second discrete chemical form of meropenem at clinically relevant concentrations prepared from the marketed formulation of the drug. Proton and carbon-13 NMR spectra in D2O, coupled with tandem mass spectroscopy (MS/MS) and cross polarization/magic angle spinning (CP-MAS) NMR experiments, allow structural assignment of the compound as a covalent carbon dioxide adduct of meropenem. This carbon dioxide adduct exists in equilibrium with the free drug in solution and can be observed in the solid state following lyophilization. The equilibrium constant of formation of the adduct (Keq = 20 +/- 8 M-1) was estimated in D2O at 25 degreesC.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Almarsson O,Kaufman MJ,Stong JD,Wu Y,Mayr SM,Petrich MA,Williams JMdoi
10.1021/js970370usubject
Has Abstractpub_date
1998-05-01 00:00:00pages
663-6issue
5eissn
0022-3549issn
1520-6017pii
10.1021/js970370ujournal_volume
87pub_type
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