Transport in quantitative structure-activity relationships. VI: Relationship between transport rate constants and partition coefficients.

Abstract:

:The transport rate constant of a drug partitioned in a two-phase system from an aqueous to an organic phase (k1obs) and vice versa (k2obs) is a function of the partition coefficient P and of a solvent system-dependent parameter beta. Drug transport is shown to be independent of molecular structure for a number of arbitrary compounds.

journal_name

J Pharm Sci

authors

van de Waterbeemd H,van Bakel P,Jansen A

doi

10.1002/jps.2600700930

subject

Has Abstract

pub_date

1981-09-01 00:00:00

pages

1081-2

issue

9

eissn

0022-3549

issn

1520-6017

pii

S0022-3549(15)43893-6

journal_volume

70

pub_type

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