Abstract:
:Scale up of pan coating process is of high importance to the pharmaceutical and food industry. The number of process variables and their interdependence in a pan coating process can make it a rather complex scale-up problem. This review discusses breaking down the coating process variables into three main categories: pan-related, spray-related, and thermodynamic-related factors. A review on how to scale up each of these factors is presented via two distinct strategies--"macroscopic" and "microscopic" scale-up. In a Quality by Design paradigm, where an increased process understanding is required, there is increased emphasis on "microscopic" scale-up, which by definition ensures a more reproducible process and thereby robust scale-up. This article also reviews the various existing and new modeling and process analytical technology tools that can provide additional information to facilitate a more fundamental understanding of the coating process.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Agrawal AM,Pandey Pdoi
10.1002/jps.24582subject
Has Abstractpub_date
2015-11-01 00:00:00pages
3589-3611issue
11eissn
0022-3549issn
1520-6017pii
S0022-3549(16)30150-2journal_volume
104pub_type
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