Stable isotope coadministration methodology for the estimation of the fraction of imipramine metabolized to desipramine.

Abstract:

:The application of a stable isotope coadministration technique for estimating the fraction (fm) of imipramine (IP) that is converted to desipramine (DMI) is described. Four healthy male subjects received 25 mg of IP-d4 hydrochloride orally with 25 mg of DMI hydrochloride. The plasma concentrations of IP-d4, DMI-d4, and DMI were determined by capillary gas chromatography-mass spectrometry-selected ion monitoring using d8 analogues as internal standards. The fm values, calculated from the ratio of the area under the plasma concentration-time curve of DMI-d4 to that of DMI, varied from 0.54 to 0.85.

journal_name

J Pharm Sci

authors

Sasaki Y,Shinohara Y,Baba S

doi

10.1002/jps.2600790203

subject

Has Abstract

pub_date

1990-02-01 00:00:00

pages

96-8

issue

2

eissn

0022-3549

issn

1520-6017

pii

S0022-3549(15)48174-2

journal_volume

79

pub_type

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