Abstract:
:The application of a stable isotope coadministration technique for estimating the fraction (fm) of imipramine (IP) that is converted to desipramine (DMI) is described. Four healthy male subjects received 25 mg of IP-d4 hydrochloride orally with 25 mg of DMI hydrochloride. The plasma concentrations of IP-d4, DMI-d4, and DMI were determined by capillary gas chromatography-mass spectrometry-selected ion monitoring using d8 analogues as internal standards. The fm values, calculated from the ratio of the area under the plasma concentration-time curve of DMI-d4 to that of DMI, varied from 0.54 to 0.85.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Sasaki Y,Shinohara Y,Baba Sdoi
10.1002/jps.2600790203subject
Has Abstractpub_date
1990-02-01 00:00:00pages
96-8issue
2eissn
0022-3549issn
1520-6017pii
S0022-3549(15)48174-2journal_volume
79pub_type
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