Abstract:
:Formulation pH has been reported to be responsible for the incidence of phlebitis. In this study, the effect of pH on injection phlebitis is investigated. Buffers of varying pHs were examined for their ability to produce phlebitis in rabbits. Thermal measurements as well as visual evaluations were used for phlebitis quantitation. The results show that formulation pH between 3.0 and 11.0 does not contribute to the incidence of phlebitis when administered as an iv bolus injection.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Simamora P,Pinsuwan S,Alvarez JM,Myrdal PB,Yalkowsky SHdoi
10.1002/jps.2600840427subject
Has Abstractpub_date
1995-04-01 00:00:00pages
520-2issue
4eissn
0022-3549issn
1520-6017pii
S0022-3549(15)49754-0journal_volume
84pub_type
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