Abstract:
:The mechanism of drug loading in cross-linked polymers was studied by X-ray photoelectron spectroscopy (XPS). This gave the atomic composition of the surface layers of the loaded polymeric particles so that the exact location of the drug molecules could be identified. Three different lots of popcorn crospovidone and a chemically cross-linked povidone were loaded by solvent swelling, with griseofulvin chosen as the drug model. The resulting drug-polymer systems were characterized by XPS, differential scanning calorimetry, X-ray diffractometry, and electron scanning microscopy. The XPS technique was found to give interesting information on the griseofulvin distribution in the polymeric particles.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Carli F,Garbassi Fdoi
10.1002/jps.2600740911subject
Has Abstractpub_date
1985-09-01 00:00:00pages
963-7issue
9eissn
0022-3549issn
1520-6017pii
S0022-3549(15)46840-6journal_volume
74pub_type
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