Abstract：
:Even though gelatin is the most widely used polymeric excipient in pharmaceutical products, scant attention has been paid to its interaction with small organic molecules. The present work deals with the interaction of gelatin and four monosulfonated or monocarboxylated azo dyes having hydrocarbon moieties of different sizes. These dyes were used as models for anionic drugs, which make up a significant percentage of all new drugs. Most binding studies used ultrafiltration to separate free from bound dye, followed by spectrophotometric dye assays. One binding study was based on the shift in pH when a dye was added to gelatin solutions. All binding isotherms consisted of two linear segments. The initial segments, which start at the origin, represent the partitioning of the dyes between the dissolved gelatin and the aqueous buffer solution. They changed abruptly to horizontal plateaus, which represent the binding limit. Increases in pH from 5.00 to 7.00 reduced the binding of the sulfonated dyes but increased the binding of the carboxylated dye. At pH > or = 7.00, where even the carboxylic acid groups are fully ionized, the carboxylated dye and its sulfonated analog were bound to gelatin to the same extent. The binding of all dyes decreased with increasing temperature (i.e., the standard enthalpy of binding was negative), with a change of the solvent medium from water to 0.15 M ammonium acetate, and with decreasing size of the hydrocarbon moieties of the dyes. The binding of the dyes to gelatin was always reversible and the standard entropy change associated with it was negative.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Gautam J,Schott Hdoi
10.1002/jps.2600830703subject
Has Abstractpub_date
1994-07-01 00:00:00pages
922-30issue
7eissn
0022-3549issn
1520-6017pii
S0022-3549(15)49539-5journal_volume
83pub_type
杂志文章abstract：:In vivo studies were conducted in rats to determine the role of hyperglycemia and hypoinsulinemia in the previously reported reduction in the hepatic accumulation and increase in the serum concentrations of 70-kDa fluorescein-dextran (FD-70) in diabetic (D) rats. The serum, urine, and hepatic concentrations of FD-70 w...
journal_title：Journal of pharmaceutical sciences
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更新日期：1994-07-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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更新日期：1977-09-01 00:00:00
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更新日期：1995-09-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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doi：10.1002/jps.2600640206
更新日期：1975-02-01 00:00:00
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更新日期：2001-03-01 00:00:00
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doi：10.1002/jps.2600680438
更新日期：1979-04-01 00:00:00
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更新日期：1975-09-01 00:00:00
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journal_title：Journal of pharmaceutical sciences
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doi：10.1002/jps.2600801207
更新日期：1991-12-01 00:00:00
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更新日期：2011-12-01 00:00:00
