Abstract:
:A colorimetric procedure for benzocaine and a number of its dosage forms was developed; it offers improvement in ease, speed, and sensitivity over the official method. The method is based on the formation of a red Schiff base between benzocaine and p-dimethylaminocinnamaldehyde in a nonaqueous acidic medium. At the maximum absorption of 544 nm, the Beer-Lambert law was adhered to over the 0.025--2.5-microgram/ml range. Best accuracy can be obtained for solutions containing 0.25--1.25 microgram/ml. The color was stable for at least 2 hr. Analysis of benzocaine in the dosage forms studied can be directly performed without prior drug extraction.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Tan HS,Bruemmer GA,Shelton Ddoi
10.1002/jps.2600660736subject
Has Abstractpub_date
1977-07-01 00:00:00pages
1037-9issue
7eissn
0022-3549issn
1520-6017pii
S0022-3549(15)39429-6journal_volume
66pub_type
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