Inulin hydrogels as carriers for colonic drug targeting. Rheological characterization of the hydrogel formation and the hydrogel network.


:Free radical polymerization converts aqueous solutions of methacrylated inulin into cross-linked hydrogels. The purpose of this work was to study the hydrogel formation and to characterize the fully cured hydrogels. The gelation process of aqueous solutions of methacrylated inulin was monitored as a function of time by means of linear oscillatory shear measurements, at a fixed frequency and amplitude. The fully cured inulin hydrogels were characterized by measurement of the frequency-dependency of the linear elastic modulus G'. The effects of the degree of substitution and feed concentration of methacrylated inulin on both the gelation kinetics and the rigidity of the obtained hydrogels were determined. The effect of the concentration of the initiators of the radical polymerization reaction has been studied as well. The weight fraction of polymer which was not incorporated in the hydrogel networks was determined using the anthrone reaction, and physical chain entanglements were determined by solution viscosity measurements. The gelation kinetics and the elastic modulus were proportional to the degree of substitution and feed concentration of methacrylated inulin. Increasing concentrations of radical-forming compounds also accelerated the hydrogel formation, but lowered the elastic modulus of the obtained hydrogels. The amount of polymer chains incorporated in the hydrogel network seemed to be especially influenced by the degree of substitution of the derivatized inulin, and for a feed concentration of 27% w/w of methacrylated inulin, entanglements have to be accounted for. The gelation kinetics and the elastic modulus of inulin hydrogels are not only affected by the degree of substitution and the feed concentration of methacrylated inulin, but also by the concentration of the initiators of the free radical polymerization reaction.


J Pharm Sci


Vervoort L,Vinckier I,Moldenaers P,Van den Mooter G,Augustijns P,Kinget R




Has Abstract


1999-02-01 00:00:00














  • Stress Temperature Studies in Small Scale Hastelloy® Drug Substance Containers Lead to Increased Extent of and Increased Variability in Antibody-Drug Conjugate and Monoclonal Antibody Aggregation: Evidence for Novel Oxidation-Induced Crosslinking in Monoc

    abstract::Health authorities require that suitable stability of the drug substance be shown in relevant materials of construction. ICH Q1A(R2) explicitly states that "stability studies should be conducted on drug substance packaged in a container closure system that is the same as or simulates the packaging proposed for storage...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Klair N,Kim MT,Lee A,Xiao NJ,Patel AR

    更新日期:2020-10-07 00:00:00

  • General linearized biexponential model for QSAR data showing bilinear-type distribution.

    abstract::A major impediment of many QSAR-type analyses is that the data show a maximum or minimum and can no longer be adequately described by linear functions that provide unrivaled simplicity and usually give good description over more restricted ranges. Here, a general linearized biexponential (LinBiExp) model is proposed t...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Buchwald P

    更新日期:2005-11-01 00:00:00

  • Compatibility, physical stability, and characterization of an IgG4 monoclonal antibody after dilution into different intravenous administration bags.

    abstract::The physical stability of an immunoglobulin G4 monoclonal antibody (mAb) upon dilution into intravenous (i.v.) bags containing 0.9% saline was examined. Soluble aggregates and subvisible particles were observed by size-exclusion high-performance liquid chromatography (SE-HPLC) and light obscuration when formulated wit...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Kumru OS,Liu J,Ji JA,Cheng W,Wang YJ,Wang T,Joshi SB,Middaugh CR,Volkin DB

    更新日期:2012-10-01 00:00:00

  • Rapid determination of chlorpromazine hydrochloride and two oxidation products in various pharmaceutical samples using high-performance liquid chromatography and fluorescence detection.

    abstract::A rapid, simple, and accurate high-performance liquid chromatographic procedure using an amino-bonded microparticulate column is reported for the determination of chlorpromazine hydrochloride (I) and its two oxidation products, the sulfoxide (II) and the sulfone (III), in commercially available pharmaceutical dosage p...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Takahashi DM

    更新日期:1980-02-01 00:00:00

  • Calorimetric relaxation and the glass-liquid temperature range of acetaminophen-nifedipine alloys.

    abstract::Glassy states of nine acetaminophen-nifedipine compositions have been made by slowly supercooling their melts, and calorimetric T(g) and the nonexponential, nonlinear relaxation parameters beta and x that are used in modeling the mobility of a pharmaceutical determined. The T(g)-endotherm's shape varies with the alloy...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Johari GP,Shanker RM

    更新日期:2008-08-01 00:00:00

  • Onset of enzyme induction with pregnenolone-16alpha-carbonitrile in male and female rats.

    abstract::Male and female rats treated with a single 20-mg/kg ip dose of pregnenolone-16alpha-carbonitrile (PCN) produced parallel increases in hepatic cytochrome P-450 and aniline hydroxylase activity. However, the onset of increase in aniline hydroxylase activity and cytochrome P-450 content was slower in male than female ani...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Stohs SJ,Rosenberg H

    更新日期:1976-04-01 00:00:00

  • Preparation and evaluation of Eudragit gels. III: Rectal gel preparations for sustained release of pentoxifylline.

    abstract::A novel method was established for the preparation of Eudragit S, Eudragit L, and Eudispert high-viscosity (hv) hydrogel and xerogel preparations containing a medicinal component such as pentoxifylline (an agent that improves cerebral microcirculation). A significant correlation was found between the in vitro mean dis...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Kim NS,Kawata M,Uchida T,Goto S

    更新日期:1992-06-01 00:00:00

  • Nasal absorption of dihydroergotamine from liquid and powder formulations in rabbits.

    abstract::Nasal drug delivery is an interesting route of administration for dihydroergotamine in migraine therapy. The currently available formulation contains dihydroergotamine at 4 mg/mL. For a nasal dose of 2 mg, a volume of 0.5 mL has to be administered, which sometimes leads to spillage of the formulation. The aim of the p...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Marttin E,Romeijn SG,Verhoef JC,Merkus FW

    更新日期:1997-07-01 00:00:00

  • Kinetic steric factors and connectivity indices.

    abstract::In this study the relationships between previously reported connectivity indices described by Kier and Hall and steric contributions to the rate constants for several series of reactions are examined. Rate data were examined for four different series of reactions, which were chosen to represent a range of different re...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Schug JC,Viers JW,Seeman JI

    更新日期:1984-10-01 00:00:00

  • Plasma levels following single and repeated doses of erythromycin estolate and erythromycin stearate.

    abstract::The pharmacokinetics of erythromycin and erythromycin 2'-propanoate were studied in healthy male volunteers following single and repeated doses of erythromycin stearate tablets, erythromycin estolate capsules, and a suspension. Estolate dosages gave rise to higher plasma levels of total drug than the stearate. However...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Welling PG,Elliott RL,Pitterle ME,Corrick-West HP,Lyons LL

    更新日期:1979-02-01 00:00:00

  • In Situ Lipolysis and Synchrotron Small-Angle X-ray Scattering for the Direct Determination of the Precipitation and Solid-State Form of a Poorly Water-Soluble Drug During Digestion of a Lipid-Based Formulation.

    abstract::In situ lipolysis and synchrotron small-angle X-ray scattering (SAXS) were used to directly detect and elucidate the solid-state form of precipitated fenofibrate from the digestion of a model lipid-based formulation (LBF). This method was developed in light of recent findings that indicate variability in solid-state f...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Khan J,Hawley A,Rades T,Boyd BJ

    更新日期:2016-09-01 00:00:00

  • Indolizine derivatives with biological activity IV: 3-(2-Aminoethyl)-2-methylindolizine, 3-(2-aminoethyl)-2-methyl-5,6,7,8-tetrahydroindolizine, and their N-alkyl derivatives.

    abstract::In a continuing search for new biologically active agents derived from indolizine, 3-(2-aminoethyl)-2-methylindolizine, 3-(2-aminoethyl)-2-methyl-5,6,7,8-tetrahydroindolizine, and some mono- and di-N-substituted derivatives were prepared. Initial pharmacological screening showed that these compounds possess anti-5-hyd...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Antonini I,Claudi F,Gulini U,Micossi L,Venturi F

    更新日期:1979-03-01 00:00:00

  • Chlorothiazide is a substrate for the human uptake transporters OAT1 and OAT3.

    abstract::The thiazide diuretic chlorothiazide is poorly metabolized, and is predominantly excreted via the kidneys. We have previously shown that chlorothiazide is transported by ATP-binding cassette transporter G2, suggesting a potential role for this transporter in apical efflux of chlorothiazide in the kidney. However, beca...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Juhász V,Beéry E,Nagy Z,Bui A,Molnár E,Zolnerciks JK,Magnan R,Jani M,Krajcsi P

    更新日期:2013-05-01 00:00:00

  • Reduced hydrolytic lability of epoprostenol in the presence of cationic micelles.

    abstract::The rapid hydrolysis of epoprostenol to 6-keto-prostaglandin F1 alpha is hydronium ion-catalyzed even at pH 10 or higher. In the presence of 1.0% hexadecyltrimethylammonium chloride, the rate was reduced significantly (1580-fold at pH 2 and 283-fold at a physiological pH). This decrease in the hydrolysis rate is attri...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Cho MJ

    更新日期:1982-04-01 00:00:00

  • Injectable polyanhydride granules provide controlled release of water-soluble drugs with a reduced initial burst.

    abstract::A method for preparing polyanhydride granules of an injectable size was developed. The resulting granules permitted a nearly constant release of low-molecular-weight, water-soluble drugs without an initial burst. The polyanhydrides used were poly(fatty acid dimer), poly(sebacic acid), and their copolymers. The dyes ac...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Tabata Y,Domb A,Langer R

    更新日期:1994-01-01 00:00:00

  • Development of HPLC conditions for valid determination of hydrolysis products of cisplatin.

    abstract::In water, the antineoplastic drug cisplatin, cis-[PtCl2(NH3)2] (1) hydrolyses slowly to the aqua complexes cis-[Pt(NH3)2Cl(H2O)]+ (2) and, to a small extent, cis-[Pt(NH3)2(H2O)2]2+ (3), which are thought to play an important role in the metabolism of cisplatin. HPLC is a useful technique for monitoring 2 and 3, but on...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: El-Khateeb M,Appleton TG,Charles BG,Gahan LR

    更新日期:1999-03-01 00:00:00

  • In vitro evaluation of the permeation-enhancing effect of thiolated polycarbophil.

    abstract::The objective of this study was to investigate the permeation-enhancing effect of thiolated polycarbophil (PCP) on peptide drugs. Mediated by a carbodiimide, increasing amounts of cysteine (Cys) were covalently bound to sodium neutralized PCP (NaPCP). The extent of covalently attached Cys was determined by quantifying...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Clausen AE,Bernkop-Schnürch A

    更新日期:2000-10-01 00:00:00

  • Isomerization of ceftibuten in aqueous solution.

    abstract::The isomerization reactions of ceftibuten and ceftibuten-related compounds in aqueous solution were investigated to estimate the substitution effect on the isomerization reaction and identify the three proximal dissociation constants of ceftibuten kinetically from the pH-rate profiles. The isomerization reaction of ce...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Hashimoto N,Hirano K

    更新日期:1998-09-01 00:00:00

  • In vivo and ex vivo evaluation of a multi-particulate composite construct for sustained transbuccal delivery of carbamazepine.

    abstract::Carbamazepine (CBZ) is a leading molecule in the management of epilepsy. Surveys have revealed that a sufficient lack of therapeutically efficient CBZ transbuccal formulation exists. Therefore, this investigation was directed toward designing multiparticulate composite construct (MCC) for the transbuccal delivery of C...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Adeleke OA,Choonara YE,Du Toit LC,Pillay V

    更新日期:2014-04-01 00:00:00

  • Characterization of the Partition Rate of Ibuprofen Across the Water-Octanol Interface and the Influence of Common Pharmaceutical Excipients.

    abstract::This work reports the measurement of the partition rate of a model drug, ibuprofen (IBU), from aqueous solutions into octanol in the absence and presence of common pharmaceutical excipients including glucose, lactose, maltoheptaose, hydroxypropyl methylcellulose, polyvinylpyrrolidone, polyvinylpyrrolidone-vinyl acetat...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Xu H,Wang W,Shi Y,Gao P

    更新日期:2019-01-01 00:00:00

  • Assessment of Bioequivalence of Weak Base Formulations Under Various Dosing Conditions Using Physiologically Based Pharmacokinetic Simulations in Virtual Populations. Case Examples: Ketoconazole and Posaconazole.

    abstract::Postabsorptive factors which can affect systemic drug exposure are assumed to be dependent on the active pharmaceutical ingredient (API), and thus independent of formulation. In contrast, preabsorptive factors, for example, hypochlorhydria, might affect systemic exposure in both an API and a formulation-dependent way....

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Cristofoletti R,Patel N,Dressman JB

    更新日期:2017-02-01 00:00:00

  • Kinetic analysis of enantiomers of threo-methylphenidate and its metabolite in two healthy subjects after oral administration as determined by a gas chromatographic-mass spectrometric method.

    abstract::A gas chromatographic-mass spectrometric method was developed for the stereoselective quantification of threo-methylphenidate (MPD) and its metabolite, ritalinic acid (RA), in plasma or urine. The plasma concentrations of (+)-MPD after oral administration of two 10-mg conventional tablets containing racemic MPD.HCl or...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Aoyama T,Kotaki H,Honda Y,Nakagawa F

    更新日期:1990-06-01 00:00:00

  • Intrinsic factor-mediated binding of cyanocobalamin to cholestyramine.

    abstract::The intrinsic factor-mediated binding of cyanocobalamin to cholestyramine was studied in vitro under varying conditions of pH, added electrolyte, and bile salt. The intrinsic factor-cyanocobalamin complex was adsorbed strongly by the resin at pH 3 in the presence of neutral salt and low concentrations of glycocholic a...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Andersen KJ,Schjønsby H

    更新日期:1978-11-01 00:00:00

  • The role of BCS (biopharmaceutics classification system) and BDDCS (biopharmaceutics drug disposition classification system) in drug development.

    abstract::Biopharmaceutics Classification System and Biopharmaceutics Drug Distribution Classification System are complimentary, not competing, classification systems that aim to improve, simplify, and speed drug development. Although both systems are based on classifying drugs and new molecular entities into four categories us...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章,评审


    authors: Benet LZ

    更新日期:2013-01-01 00:00:00

  • Secondary antithyroid action of drugs in relation to structure.

    abstract::Molecular interactions between iodine and disulfiram, clomethiazole, and tolnaftate were investigated by electron spectroscopy. Iodine forms charge transfer complexes with these molecules, with 1:1 stoichiometry and of the n-sigma type. The formation constants were compared with those obtained with antithyroid molecul...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Buxeraud J,Absil AC,Raby C

    更新日期:1984-12-01 00:00:00

  • Binding of (+)- and (-)-isomers and racemate of etomoxir to human serum albumin and effect of stearic acid and stanozolol.

    abstract::Binding of (+)- and (-)-isomers and the racemate of sodium 2[6-(4-chlorophenoxy)-hexyl]-oxiran-2-carboxylate dihydrat (etomoxir) to the human serum albumin (HSA) was studied by the gel filtration method. The experimental results are presented graphically using the method of Scatchard. Measurements revealed the followi...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Vestemar V,Medic-Saric M,Rendic S

    更新日期:1994-04-01 00:00:00

  • On the identification of slip planes in organic crystals based on attachment energy calculation.

    abstract::Knowledge of slip or cleavage planes can facilitate the fundamental understanding of mechanical properties of organic crystals important to pharmaceutical operations, such as tableting and milling. Slip/cleavage planes were frequently assigned based on attachment energy calculation. These crystallographic planes can a...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Sun CC,Kiang YH

    更新日期:2008-08-01 00:00:00

  • Synthesis and antibacterial evaluation of 2-(substituted phenylureido)-4-thiocyanatobenzothiazoles.

    abstract::The synthesis and antibacterial evaluation of a number of 2-(substituted phenylureido)-4-thiocyanatobenzothiazoles are described. The more active compounds against the test organisms in vitro generally were those substituted with halogens on the phenyl and benzothiazole rings. ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Alaimo RJ,Pelosi SS,Freedman R

    更新日期:1978-02-01 00:00:00

  • Steroidal thiourea and thiazoline derivatives: synthesis and in vitro effects on bovine pancreatic ribonuclease activity.

    abstract::Two novel series of steroidal derivatives containing various thiourea and substituted thiazoline moieties attached to the 2- or 4-position of estrone were synthesized and examined for in vitro effect on bovine pancreatic ribonuclease activity. All compounds studied exhibited a catabolic activity. The steroidal thiazol...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Ibrahim ES,Omar AM,Habib NS,Aboulwafa OM,El-Sewedy SM,Bourdais J

    更新日期:1983-10-01 00:00:00

  • Physicochemical and pharmacokinetic characteristics of plasmid DNA/cationic liposome complexes.

    abstract::The objectives of this study were (i) to characterize the plasmid DNA encoding the chloramphenicol acetyltransferase reporter gene (pCAT) complexed with cationic liposomes (Lipofectin and LipofectACE) in terms of particle size and zeta potential, (ii) to compare pharmacokinetic characteristics, and (iii) to study the ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Mahato RI,Kawabata K,Nomura T,Takakura Y,Hashida M

    更新日期:1995-11-01 00:00:00