Abstract:
:A novel drug-deliver device based on a self-setting bioactive cement formed from tetracalcium phosphate and dicalcium phosphate has been developed and tested in vitro using bovine insulin and bovine albumin as model polypeptide drugs. Equimolar mixtures of the calcium phosphate powders containing bovine insulin and bovine albumin were transformed into a hydroxyapatite cement after being mixed with a dilute phosphoric acid solution. X-ray diffraction and FT-IR spectra results suggested that the raw materials transformed into lower crystallinity of hydroxyapatite as it hardened. In vitro drug release from cement pellets into a 0.1 mol/L phosphate buffer at pH 7.40 and 37 degrees C continued for more than 3 weeks. Release from the drug-loaded cements followed the Higuchi model equation.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Otsuka M,Matsuda Y,Suwa Y,Fox JL,Higuchi WIdoi
10.1002/jps.2600830229subject
Has Abstractpub_date
1994-02-01 00:00:00pages
255-8issue
2eissn
0022-3549issn
1520-6017pii
S0022-3549(15)49351-7journal_volume
83pub_type
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abstract::Acyclovir is an antiviral drug poorly absorbed in the gastrointestinal tract due to its hydrophilicity, with low oral bioavailability (~20%). Although acyclovir is prescribed in the management of herpes simplex encephalitis (HSE), the disease has a poor prognosis, particularly if the treatment is delayed, reaching mor...
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