Stability of apomorphine in solutions containing ascorbic acid and bisulfite and effects of antioxidants on apomorphine-induced cage climbing and hypothermia in mice.

Abstract:

:Ascorbic acid (100 mg/ml) and sodium bisulfite (0.5 and 20 mg/ml) prevented more than 10% oxidation of apomorphine hydrochloride in water maintained at room temperature over 1-3 days. Refrigeration at 5 degrees prevented oxidation of apomorphine hydrochloride in aqueous solutions for 1 week. Neither ascorbic acid nor sodium bisulfite affected murine stereotyped cage climbing or hypothermia induced by apaomorphine.

journal_name

J Pharm Sci

authors

Wilcox RE,Humphrey DW,Riffee WH,Smith RV

doi

10.1002/jps.2600690830

subject

Has Abstract

pub_date

1980-08-01 00:00:00

pages

974-6

issue

8

eissn

0022-3549

issn

1520-6017

pii

S0022-3549(15)43350-7

journal_volume

69

pub_type

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