Abstract:
:Deiodination of diatrizoic acid, an anionic radiopaque, was found to be catalyzed by Cu(II). Through a detailed study of o-iodobenzoic acid, a model compound, the copper-catalyzed SN1 mechanism was established based on observations of common ion, salt, and pH effects. Meta- and para-iodobenzoic acids were unreactive. Deiodination thus was facilitated by a neighboring carboxylate that attracted copper. Iopamidol, a nonionic radiopaque, also underwent deiodination. At pH 7 or above, the hydroxide-ion substitution predominated. At pH below 7, the reaction is in favor of the copper-catalyzed SN1 mechanism.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Wang YCdoi
10.1002/jps.2600690616subject
Has Abstractpub_date
1980-06-01 00:00:00pages
671-5issue
6eissn
0022-3549issn
1520-6017pii
S0022-3549(15)43224-1journal_volume
69pub_type
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