Abstract:
:A GLC method for the determination of procainamide in biological fluids is presented. By using a dipropyl analog of procainamide as an internal standard, both compounds can be chromatographed directly, yielding linear calibration curves and a sensitivity that allows quantitative determination of concentrations as low as 0.1 mug/ml. The extraction procedure was carefully modified to avoid hydrolysis of N-acetylprocainamide, a major metabolite of procainamide. The usefulness of the procedure is demonstrated by following the disappearance of procainamide from the plasma and urine of human subjects treated with the drug.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Simons KJ,Levy RHdoi
10.1002/jps.2600641213subject
Has Abstractpub_date
1975-12-01 00:00:00pages
1967-70issue
12eissn
0022-3549issn
1520-6017pii
S0022-3549(15)40571-4journal_volume
64pub_type
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