Solubility and partitioning. VII: Solubility of barbiturates in water.

Abstract:

:The solubility equation of Yalkowsky was used to estimate the aqueous solubility of 33 barbiturates in the temperature range of 5 to 45 degrees C. The equation was extended by adding a term which accounts for the effect of pH on the solubility of the drug. The extended equation is successful in estimating the aqueous solubility of this series of drugs under different conditions of temperature and pH. The results indicate that the extended equation can be used to estimate the aqueous solubility of nonelectrolytes as well as weak electrolytes.

journal_name

J Pharm Sci

authors

Pinal R,Yalkowsky SH

doi

10.1002/jps.2600760120

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

75-85

issue

1

eissn

0022-3549

issn

1520-6017

pii

S0022-3549(15)47313-7

journal_volume

76

pub_type

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