Abstract:
:The solubility equation of Yalkowsky was used to estimate the aqueous solubility of 33 barbiturates in the temperature range of 5 to 45 degrees C. The equation was extended by adding a term which accounts for the effect of pH on the solubility of the drug. The extended equation is successful in estimating the aqueous solubility of this series of drugs under different conditions of temperature and pH. The results indicate that the extended equation can be used to estimate the aqueous solubility of nonelectrolytes as well as weak electrolytes.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Pinal R,Yalkowsky SHdoi
10.1002/jps.2600760120subject
Has Abstractpub_date
1987-01-01 00:00:00pages
75-85issue
1eissn
0022-3549issn
1520-6017pii
S0022-3549(15)47313-7journal_volume
76pub_type
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