Rapid determination of gold in whole blood of arthritis patients using flameless atomic absorption spectrophotometry.


:An assay for gold in whole blood of arthritis patients was developed using the graphite furnace atomic absorption spectrophotometer. This method involves no pretreatment of the whole blood except for simple dilution, thereby eliminating some variables and saving laboratory time and expense.


J Pharm Sci


Barrett MJ,DeFries R,Henderson WM




Has Abstract


1978-09-01 00:00:00














  • Stability of aqueous solutions of pirbuterol.

    abstract::The hydrolytic degradation of pirbuterol was investigated under saturated oxygen conditions over a wide range of pH values and at different temperatures. Two of the five observed breakdown products were positively identified. The first-order decomposition rate appeared to depend on the rate constants of the four disso...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Bansal PC,Monkhouse DC

    更新日期:1977-06-01 00:00:00

  • Amino acid analogs IV:4-fluoroisoleucine.

    abstract::4-Fluoroisoleucine was produced by ammonolysis of 2-bromo-4-fluoro-3-methylpentanoic acid, which resulted from the bromofluorination of 4-methyl-2-pentenoic acid. It did not inhibit Plasmodium berghei in mice at 640 mg/kg and was not toxic to the animals. The fluoroamino acid inhibited Aspergillus niger, Trichoderma v...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Gershon H,Shanks L,Clarke DD

    更新日期:1978-05-01 00:00:00

  • Preparation of pH-sensitive beads for NSAID using three-component gel systems.

    abstract::The aim of this study is to prepare novel pH-sensitive beads to obtain a gastric mucosa protective formulation and to ensure drug delivery into the intestine. Diclofenac sodium was used as a model drug. Bead formation was achieved by ionotropic gelation method using three-component gel system containing sodium alginat...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Fenyvesi Z,Auner A,Schmalz D,Pásztor E,Csóka G,Gyires K,Marton S,Klebovich I,Antal I

    更新日期:2009-11-01 00:00:00

  • Explication of Definitional Description and Empirical Use of Fraction of Orally Administered Drugs Absorbed From the Intestine (Fa) and Intestinal Availability (Fg): Effect of P-glycoprotein and CYP3A on Fa and Fg.

    abstract::Conventionally, it is believed that the fraction of orally administered drugs absorbed from the intestine (Fa) and intestinal availability (Fg) are independently determined by the apical membrane permeation and intestinal metabolism, respectively. However, the validity of this belief has not been well discussed, and F...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章,评审


    authors: Tanaka Y,Kitamura Y,Maeda K,Sugiyama Y

    更新日期:2016-02-01 00:00:00

  • Preformulation and pharmacokinetic studies on antalarmin: a novel stress inhibitor.

    abstract::The preformulation, solubilization and pharmacokinetic evaluation of antalarmin, a stress inhibitor, have been conducted. Antalarmin has a poor water solubility of less than 1 microg/mL and is weakly basic with an experimentally determined pK(a) of 5.0. Multiple solubilization approaches including pH-control either al...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Sanghvi R,Mogalian E,Machatha SG,Narazaki R,Karlage KL,Jain P,Tabibi SE,Glaze E,Myrdal PB,Yalkowsky SH

    更新日期:2009-01-01 00:00:00

  • Metabolism of carprofen, a nonsteroid anti-inflammatory agent, in rats, dogs, and humans.

    abstract::The metabolic disposition of 14C-labeled carprofen [(+/-)-6-chloro-alpha-methylcarbazole-2-acetic acid] was investigated in rats, dogs, and humans. Carprofen is eliminated predominantly by biotransformation in these three species. In dogs and rats, the direct conjugation of carprofen to form an ester glucuronide and o...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Rubio F,Seawall S,Pocelinko R,DeBarbieri B,Benz W,Berger L,Morgan L,Pao J,Williams TH,Koechlin B

    更新日期:1980-11-01 00:00:00

  • Colorimetric assay of benzocaine and some dosage forms.

    abstract::A colorimetric procedure for benzocaine and a number of its dosage forms was developed; it offers improvement in ease, speed, and sensitivity over the official method. The method is based on the formation of a red Schiff base between benzocaine and p-dimethylaminocinnamaldehyde in a nonaqueous acidic medium. At the ma...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Tan HS,Bruemmer GA,Shelton D

    更新日期:1977-07-01 00:00:00

  • Rational coformer or solvent selection for pharmaceutical cocrystallization or desolvation.

    abstract::It is demonstrated that the fluid-phase thermodynamics theory conductor-like screening model for real solvents (COSMO-RS) as implemented in the COSMOtherm software can be used for accurate and efficient screening of coformers for active pharmaceutical ingredient (API) cocrystallization. The excess enthalpy, H(ex) , be...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Abramov YA,Loschen C,Klamt A

    更新日期:2012-10-01 00:00:00

  • Synthesis and cytotoxic evaluation of some cyclic arylidene ketones and related oximes, oxime esters, and analogs.

    abstract::A number of arylidene derivatives of alicyclic ketones and some corresponding oximes, oxime esters, and related compounds were prepared as candidate cytotoxic agents. All of the compounds were evaluated against murine L1210 lymphoid leukemia cells. In general, cytotoxicity was greatest with the alpha,beta-unsaturated ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Dimmock JR,Sidhu KK,Chen M,Li J,Quail JW,Allen TM,Kao GY

    更新日期:1994-06-01 00:00:00

  • Quantitation of the area of overlap between second-derivative amide I infrared spectra to determine the structural similarity of a protein in different states.

    abstract::Maintaining a native-like structure of protein pharmaceuticals during lyophilization is an important aspect of formulation. Infrared spectroscopy can be used to evaluate the effectiveness of formulations in protecting the secondary structural integrity of proteins in the dried solid. This necessitates making quantitat...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Kendrick BS,Dong A,Allison SD,Manning MC,Carpenter JF

    更新日期:1996-02-01 00:00:00

  • Nonisothermal kinetic studies III: rapid nonisothermal-isothermal method for stability prediction.

    abstract::A continuous nonisothermal-isothermal method for stability prediction was developed. The approach yields all necessary parameters for prediction, including reaction order. The experimental procedure involves changing the temperature of the samples being studied until degradation is rapid enough to proceed at a conveni...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Zoglio MA,Maulding HV,Streng WH,Vincek WC

    更新日期:1975-08-01 00:00:00

  • Usefulness of PBPK Modeling in Incorporation of Clinical Conditions in Personalized Medicine.

    abstract::Personalized medicine aims to determine the most adequate treatment and dose regimen to obtain the maximum efficacy and minimum side effect by taking into account patients' characteristics. For numerous reasons, one being ethical and methodological hurdles in including specific populations in clinical trials, innovati...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章,评审


    authors: Marsousi N,Desmeules JA,Rudaz S,Daali Y

    更新日期:2017-09-01 00:00:00

  • Determination of azobenzene and hydrazobenzene in phenylbutazone and sulfinpyrazone products by high-performance liquid chromatography.

    abstract::A high-performance liquid chromatographic method has been developed for the simultaneous determination of azobenzene and hydrazobenzene in phenylbutazone and sulfinpyrazone raw materials and formulations. The drug raw material or formulation is shaken with 1N NaOH and n-hexane and centrifuged. The n-hexane layer is in...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Matsui F,Lovering EG,Curran NM,Watson JR

    更新日期:1983-10-01 00:00:00

  • Delivery of theophylline into excised human skin from alkanoic acid solutions: a "push-pull" mechanism.

    abstract::Human skin samples are permeable to theophylline delivered from 1.5% solutions in various alkanecarboxylic acids and their mixtures. The respective permeability coefficients of theophylline, calculated from steady-state flux, correlate negatively with the permeability coefficients of the donor carboxylic acids and pos...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Kadir R,Stempler D,Liron Z,Cohen S

    更新日期:1987-10-01 00:00:00

  • Determination of ketoprofen by direct injection of deproteinized body fluids into a high-pressure liquid chromatographic system.

    abstract::A rapid, sensitive, and specific determination of ketoprofen in human and animal deproteinized body fluids by reversed-phase high-pressure liquid chromatography is presented. The acid is detectable in amounts as low as 0.1 microgram/ml. Limits of error are in the range of +/- 5.1% of the sample mean. ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Ballerini R,Cambi A,Del Soldato P,Melani F,Meli A

    更新日期:1979-03-01 00:00:00

  • Long-term controlled navel administration of testosterone.

    abstract::Male fertility has reportedly been regulated by the long-term, continuous administration of testosterone. To deliver the testosterone at a controlled rate for a month or longer, a bandage-type, testosterone-releasing, disk-shaped device was developed. In vitro drug elution studies demonstrated that a constant release ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Chien YW

    更新日期:1984-08-01 00:00:00

  • Dynamics of disinfection of selected preservatives against Escherichia coli.

    abstract::Mathematical models were determined relating preservative concentration and D values (decimal reduction times at 25 degrees C; pH 6.9-7.1) against Escherichia coli in aqueous medium. Preservatives investigated were 2-bromo-2-nitro-1,3-propanediol (Bronopol), N-(hydroxymethyl)-N-(1,3-dihydroxymethyl-2, 5-dioxo-4-imidaz...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Hurwitz SJ,McCarthy TJ

    更新日期:1985-08-01 00:00:00

  • Differences in pharmacokinetics and ex vivo antioxidant activity following intravenous and oral administrations of emodin to rats.

    abstract::Emodin, a natural anthraquinone polyphenol, has been reported to possess promising in vitro antioxidation, anticancer and anti-inflammatory activities. Whether the in vitro bioactivities can predict in vivo effects remained an unanswered question without understanding emodin pharmacokinetics in animals. To fill this b...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Shia CS,Hou YC,Tsai SY,Huieh PH,Leu YL,Chao PD

    更新日期:2010-04-01 00:00:00

  • Drug delivery trends in clinical trials and translational medicine: evaluation of pharmacokinetic properties in special populations.

    abstract::In spite of the recent advances in technology to optimize the absorption, distribution, metabolism and elimination (ADME) properties of new and promising medicinal products to reduce clinical failures, the investigation of drug disposition in the pediatric and elderly populations continues to be under evaluated. With ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章,评审


    authors: Chien JY,Ho RJ

    更新日期:2011-01-01 00:00:00

  • Chemical modifications of therapeutic proteins induced by residual ethylene oxide.

    abstract::Ethylene oxide (EtO) is widely used in sterilization of drug product primary containers and medical devices. The impact of residual EtO on protein therapeutics is of significant interest in the biopharmaceutical industry. The potential for EtO to modify individual amino acids in proteins has been previously reported. ...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Chen L,Sloey C,Zhang Z,Bondarenko PV,Kim H,Ren D,Kanapuram S

    更新日期:2015-02-01 00:00:00

  • Intrinsic factor-mediated binding of cyanocobalamin to cholestyramine.

    abstract::The intrinsic factor-mediated binding of cyanocobalamin to cholestyramine was studied in vitro under varying conditions of pH, added electrolyte, and bile salt. The intrinsic factor-cyanocobalamin complex was adsorbed strongly by the resin at pH 3 in the presence of neutral salt and low concentrations of glycocholic a...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Andersen KJ,Schjønsby H

    更新日期:1978-11-01 00:00:00

  • Comparison of 99mTc-N-pyridoxyl-5-methyltryptophan and 99mTc-N-(3-bromo-2,4,6-trimethylacetanilide)-iminodiace tate as hepatobiliary radiopharmaceuticals in rats.

    abstract::99mTc-N-(3-bromo-2,4,6-trimethylacetanilide)iminodiacetat e (I) and 99mTc-N-pyridoxyl-5-methyl-tryptophan (II) have been described as having optimal properties as hepatobiliary radiopharmaceuticals. This study compared specificity for hepatobiliary excretion, blood disappearance, rates of biliary appearance, and pharm...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Fritzberg AR,Bloedow DC,Eshima D,Johnson DL

    更新日期:1984-12-01 00:00:00

  • New method for characterizing dissolution properties of drug powders.

    abstract::Various multiparticulate dissolution models that assume a log-normal particle-size distribution are fitted by nonlinear least-squares regression to data from the dissolution of micronized glyburide. Estimates of parameters describing the effective initial particle-size distribution are obtained, together with estimate...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Pedersen PV

    更新日期:1977-06-01 00:00:00

  • The Introduction of a New Flexible In Vivo Predictive Dissolution Apparatus, GIS-Alpha (GIS-α), to Study Dissolution Profiles of BCS Class IIb Drugs, Dipyridamole and Ketoconazole.

    abstract::The physiological pH changes and peristalsis activities in gastrointestinal (GI) tract have big impact on the dissolution of oral drug products, when those oral drug products include APIs with pH-dependent solubility. It is well documented that predicting the bioperformance of those oral drug products can be challengi...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Tsume Y,Patel S,Wang M,Hermans A,Kesisoglou F

    更新日期:2020-11-01 00:00:00

  • Hepatobiliary disposition of liposomal amphotericin B in the isolated perfused rat liver.

    abstract::The hepatic distribution, biliary excretion, and mass balance of liposomal amphotericin B (L-AmB) were investigated in recirculated isolated perfused rat liver. The results were compared with those from the conventional AmB formulation, amphotericin B deoxycholate (D-AmB). L-AmB was introduced as a bolus into the perf...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Hong Y,Ramzan I,McLachlan AJ

    更新日期:2005-01-01 00:00:00

  • Novel methodology for predicting photogenotoxic risk of pharmaceutical substances based on reactive oxygen species (ROS) and DNA-binding assay.

    abstract::Drug-induced phototoxic skin responses involves photoirritation, photoallergy, and photogenotoxicity. In the present study, we attempted to develop effective analytical tools to predict the photogenotoxic potential of pharmaceutical substances on the basis of their photobiological and DNA-binding properties. Photoclea...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Onoue S,Seto Y,Oishi A,Yamada S

    更新日期:2009-10-01 00:00:00

  • Major metabolites of substance P degraded by spinal synaptic membranes antagonize the behavioral response to substance P in rats.

    abstract::Substance P (SP) was degraded by synaptic membranes of rat spinal cord. Cleavage products were separated by reversed phase high performance liquid chromatography and identified by amino acid composition analyses. Major products of SP were phenylalanine, SP(1-4), SP(1-6), SP(1-7), SP(10-11), and SP(8-9). Both the degra...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Sakurada C,Watanabe C,Sakurada S,Tan-No K,Sakurada T

    更新日期:1999-11-01 00:00:00

  • Modeling of transmitted X-ray intensity variation with sample thickness and solid fraction in glycine compacts.

    abstract::The previous paper in this series introduced an X-ray diffraction quantitation method for the polymorphic content in tablets made of pure components. Before the method could be transferred, further studies were required to explain the commonly observed X-ray intensity variation in analyzing compacts. The literature ty...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Cao W,Mullarney MP,Hancock BC,Bates S,Morris KR

    更新日期:2003-12-01 00:00:00

  • Mechanisms of potassium chloride release from compressed, hydrophilic, polymeric matrices: effect of entrapped air.

    abstract::The release of potassium chloride from hydroxypropyl methylcellulose matrices was investigated for tablets prepared with several different compression forces. It was determined that the release kinetics for these systems deviates significantly from the classical t1/2 dependence. This behavior was attributed to air ent...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Korsmeyer RW,Gurny R,Doelker E,Buri P,Peppas NA

    更新日期:1983-10-01 00:00:00

  • Microstructure of calcium stearate matrix pellets: a function of the drying process.

    abstract::Drying is a common pharmaceutical process, whose potential to modify the final drug and/or dosage form properties is often underestimated. In the present study, pellets consisting of the matrix former calcium stearate (CaSt) incorporating the active pharmaceutical ingredient ibuprofen were prepared via wet extrusion a...

    journal_title:Journal of pharmaceutical sciences

    pub_type: 杂志文章


    authors: Schrank S,Kann B,Windbergs M,Glasser BJ,Zimmer A,Khinast J,Roblegg E

    更新日期:2013-11-01 00:00:00