Abstract:
:Three analogs of thyroliberin (I) were prepared. These compounds, N-m-chloroacetylbenzoyl-phenylalanyl-prolineamide (VIa), N-p-chloroacetylbenzoyl-phenylalanyl-prolineamide (VIb) and N-chloroacetyl-alanyl-phenylalanyl-prolineamide (IX), were designed as potential I antagonist affinity labels. However, no significant antagonist activity was observed. Compounds VIa and IX were found to have weak agonist activity. Cyclo (Phe-Pro) an analog of the I metabolite, cyclo (His-Pro), was found, however, to have significant I antagonist activity, but no agonist activity.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Goebel RJ,Currie BL,Bowers CYdoi
10.1002/jps.2600710928subject
Has Abstractpub_date
1982-09-01 00:00:00pages
1062-4issue
9eissn
0022-3549issn
1520-6017pii
S0022-3549(15)44310-2journal_volume
71pub_type
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